Homocysteine and carotid plaque stability

A cross-sectional study in Chinese adults

Xin Yang, Yong Zhou, Chao Liu, Xiang Gao, Anxin Wang, Yuming Guo, Wen Li, Xingquan Zhao, Wannian Liang

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Background and Purpose: This study aimed to explore the possible association of plasma total homocysteine with carotid plaque stability. Methods: A cross-sectional study was conducted from 2010 to 2011. A stratified random sample of 2,919 Chinese participants aged 40 years or older was enrolled. Plasma total homocysteine levels were measured and carotid plaques were evaluated by ultrasonography. Logistic regression model was used to analyze the association of homocysteine levels to the progression of carotid plaque development, while adjusting for demographics and vascular risk factors. Results: The mean level of plasma homocysteine in the subjects was 14.9 mmol/l. Along with increase in homocysteine level, the risk of advanced carotid plaque elevated (odds ratio = 1.28; 95% confidence interval = 1.09-1.51) after adjusting for age, sex, and other potential confounders. Stratified by sex, higher homocysteine level was strongly associated with advanced carotid plaque in men (OR = 1.41; 95% confidence interval = 1.17-1.70), but not in women. Conclusion: The findings suggest that plasma level of homocysteine may be associated with advanced carotid plaque, which constitutes high risks of stroke, in male Chinese adults.

Original languageEnglish
Article numbere94935
Number of pages6
JournalPLoS ONE
Volume9
Issue number4
DOIs
Publication statusPublished - 15 Apr 2014
Externally publishedYes

Cite this

Yang, Xin ; Zhou, Yong ; Liu, Chao ; Gao, Xiang ; Wang, Anxin ; Guo, Yuming ; Li, Wen ; Zhao, Xingquan ; Liang, Wannian. / Homocysteine and carotid plaque stability : A cross-sectional study in Chinese adults. In: PLoS ONE. 2014 ; Vol. 9, No. 4.
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abstract = "Background and Purpose: This study aimed to explore the possible association of plasma total homocysteine with carotid plaque stability. Methods: A cross-sectional study was conducted from 2010 to 2011. A stratified random sample of 2,919 Chinese participants aged 40 years or older was enrolled. Plasma total homocysteine levels were measured and carotid plaques were evaluated by ultrasonography. Logistic regression model was used to analyze the association of homocysteine levels to the progression of carotid plaque development, while adjusting for demographics and vascular risk factors. Results: The mean level of plasma homocysteine in the subjects was 14.9 mmol/l. Along with increase in homocysteine level, the risk of advanced carotid plaque elevated (odds ratio = 1.28; 95{\%} confidence interval = 1.09-1.51) after adjusting for age, sex, and other potential confounders. Stratified by sex, higher homocysteine level was strongly associated with advanced carotid plaque in men (OR = 1.41; 95{\%} confidence interval = 1.17-1.70), but not in women. Conclusion: The findings suggest that plasma level of homocysteine may be associated with advanced carotid plaque, which constitutes high risks of stroke, in male Chinese adults.",
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Yang, X, Zhou, Y, Liu, C, Gao, X, Wang, A, Guo, Y, Li, W, Zhao, X & Liang, W 2014, 'Homocysteine and carotid plaque stability: A cross-sectional study in Chinese adults', PLoS ONE, vol. 9, no. 4, e94935. https://doi.org/10.1371/journal.pone.0094935

Homocysteine and carotid plaque stability : A cross-sectional study in Chinese adults. / Yang, Xin; Zhou, Yong; Liu, Chao; Gao, Xiang; Wang, Anxin; Guo, Yuming; Li, Wen; Zhao, Xingquan; Liang, Wannian.

In: PLoS ONE, Vol. 9, No. 4, e94935, 15.04.2014.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Yang, Xin

AU - Zhou, Yong

AU - Liu, Chao

AU - Gao, Xiang

AU - Wang, Anxin

AU - Guo, Yuming

AU - Li, Wen

AU - Zhao, Xingquan

AU - Liang, Wannian

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Y1 - 2014/4/15

N2 - Background and Purpose: This study aimed to explore the possible association of plasma total homocysteine with carotid plaque stability. Methods: A cross-sectional study was conducted from 2010 to 2011. A stratified random sample of 2,919 Chinese participants aged 40 years or older was enrolled. Plasma total homocysteine levels were measured and carotid plaques were evaluated by ultrasonography. Logistic regression model was used to analyze the association of homocysteine levels to the progression of carotid plaque development, while adjusting for demographics and vascular risk factors. Results: The mean level of plasma homocysteine in the subjects was 14.9 mmol/l. Along with increase in homocysteine level, the risk of advanced carotid plaque elevated (odds ratio = 1.28; 95% confidence interval = 1.09-1.51) after adjusting for age, sex, and other potential confounders. Stratified by sex, higher homocysteine level was strongly associated with advanced carotid plaque in men (OR = 1.41; 95% confidence interval = 1.17-1.70), but not in women. Conclusion: The findings suggest that plasma level of homocysteine may be associated with advanced carotid plaque, which constitutes high risks of stroke, in male Chinese adults.

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