Home IV Antibiotic Therapy and Exercise Capacity in Children with CF: A Case Series

Narelle S. Cox, Karen O McKay, Jennifer Follett, Jennifer A Alison

Research output: Contribution to journalArticleResearch

Abstract

Purpose: This case series describes the effect of home intravenous (IV) antibiotic therapy on spirometry and exercise capacity in a group of children with cystic fibrosis (CF). Methods: Outcomes from 10 children with CF who were prescribed a 14-day course of home IV antibiotics for a respiratory exacerbation are reported. All children performed spirometry and a modified shuttle test (MST) before and after 14-days of home IV therapy. Results: After 14 days, FEV1 increased by mean (± SE) 12 ± 4 % (p < 0.05) but mean MST did not improve compared to baseline. All children improved or maintained spirometry values with treatment, however, only 5 improved MST distance. Conclusion: After 14 days of home IV antibiotic therapy, a significant improvement in spirometry, but not exercise capacity, was seen in this small series of children with CF. The lack of improvement in exercise capacity for all children following home IV antibiotic therapy suggests factors other than spirometry determine exercise capacity. Identifying and investigating the factors that influence exercise capacity during home IV antibiotic therapy requires further investigation.
Original languageEnglish
Pages (from-to)16-19
Number of pages4
JournalCardiopulmonary Physical Therapy Journal
Volume22
Issue number1
Publication statusPublished - Mar 2011
Externally publishedYes

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