TY - JOUR
T1 - Home-based, tailored intervention for reducing falls after stroke (FAST)
T2 - Protocol for a randomized trial
AU - Dean, Catherine
AU - Clemson, Lindy
AU - Ada, Louise
AU - Scrivener, Katherine
AU - Lannin, Natasha
AU - Mikolaizak, Stefanie
AU - Day, Sally
AU - Cusick, Anne
AU - Gardner, Benjamin
AU - Heller, Gillian
AU - Isbel, Stephen
AU - Jones, Taryn
AU - Mumford, Virginia
AU - Preston, Elisabeth
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: FAST is funded by the National Health and Medical Research Council, Australia. Trial organization, data management, and monitoring is supported by The University of Sydney, Australia.
Publisher Copyright:
© 2021 World Stroke Organization.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/12
Y1 - 2021/12
N2 - Rationale: People with stroke experience falls at more than twice the rate of the general older population resulting in high fall-related injuries. However, there are currently no effective interventions that prevent falls after stroke. Aims: To determine the effect and cost-benefit of an innovative, home-based, tailored intervention to reduce falls after stroke. Sample size estimate: A total of 370 participants will be recruited in order to be able to detect a clinically important between-group difference of a 30% lower rate of falls with 80% power at a two-tailed significance level of 0.05. Methods and design: Falls after stroke trial (FAST) is a multistate, Phase III randomized trial with concealed allocation, blinded assessment, and intention-to-treat analysis. Ambulatory stroke survivors within five years of stroke who have been discharged from formal rehabilitation to the community and who have no significant language impairment will be randomly allocated to receive habit-forming exercise, home safety, and community mobility training or usual care. Study outcomes: The primary outcome is the rate of falls over the previous 12 months. Secondary outcomes are the risk of falling (proportion of fallers), community participation, self-efficacy, balance, mobility, physical activity, depression, and health-related quality of life. Health care utilization will be collected retrospectively at baseline and prospectively to 6 and 12 months. Discussion: The results of FAST are anticipated to directly influence intervention for stroke survivors in the community. Trial Registration: ANZCTR 12619001114134
AB - Rationale: People with stroke experience falls at more than twice the rate of the general older population resulting in high fall-related injuries. However, there are currently no effective interventions that prevent falls after stroke. Aims: To determine the effect and cost-benefit of an innovative, home-based, tailored intervention to reduce falls after stroke. Sample size estimate: A total of 370 participants will be recruited in order to be able to detect a clinically important between-group difference of a 30% lower rate of falls with 80% power at a two-tailed significance level of 0.05. Methods and design: Falls after stroke trial (FAST) is a multistate, Phase III randomized trial with concealed allocation, blinded assessment, and intention-to-treat analysis. Ambulatory stroke survivors within five years of stroke who have been discharged from formal rehabilitation to the community and who have no significant language impairment will be randomly allocated to receive habit-forming exercise, home safety, and community mobility training or usual care. Study outcomes: The primary outcome is the rate of falls over the previous 12 months. Secondary outcomes are the risk of falling (proportion of fallers), community participation, self-efficacy, balance, mobility, physical activity, depression, and health-related quality of life. Health care utilization will be collected retrospectively at baseline and prospectively to 6 and 12 months. Discussion: The results of FAST are anticipated to directly influence intervention for stroke survivors in the community. Trial Registration: ANZCTR 12619001114134
KW - Behaviour change
KW - community participation
KW - falls prevention
KW - home safety
KW - randomized trial
KW - stroke
UR - http://www.scopus.com/inward/record.url?scp=85100855761&partnerID=8YFLogxK
U2 - 10.1177/1747493021991990
DO - 10.1177/1747493021991990
M3 - Article
C2 - 33568018
AN - SCOPUS:85100855761
SN - 1747-4930
VL - 16
SP - 1053
EP - 1058
JO - International Journal of Stroke
JF - International Journal of Stroke
IS - 9
ER -