Hodgkin-Huxley neurons with defective and blocked ion channels

James Christopher S. Pang, Johnrob Y. Bantang

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2 Citations (Scopus)

Abstract

We utilize the original Hodgkin-Huxley (HH) model to consider the effects of defective ion channels to the temporal response of neurons. Statistics of firing rate and inter-spike interval (ISI) reveal that production of action potentials (APs) in neurons is not sensitive to changes in membrane conductance for sodium and potassium ions, as well as to the reversal potential for sodium ions, as long as the relevant parameters do not exceed 13% from their normal levels. We also found that blockage of a critical fraction of either sodium or potassium channels (dependent on constant input current) respectively limits the firing activity or increases spontaneous spiking activity of neurons. Our model may be used to guide experiment designs related to ion channel control drug development.

Original languageEnglish
Article number1550112
Number of pages14
JournalInternational Journal of Modern Physics C
Volume26
Issue number10
DOIs
Publication statusPublished - 26 Oct 2015
Externally publishedYes

Keywords

  • Defect
  • Hodgkin-Huxley neurons
  • Ion channels

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