TY - JOUR
T1 - Hobit and Blimp1 instruct a universal transcriptional program of tissue residency in lymphocytes
AU - Mackay, Laura K.
AU - Minnich, Martina
AU - Kragten, Natasja A.M.
AU - Liao, Yang
AU - Nota, Benjamin
AU - Seillet, Cyril
AU - Zaid, Ali
AU - Man, Kevin
AU - Preston, Simon
AU - Freestone, David
AU - Braun, Asolina
AU - Wynne-Jones, Erica
AU - Behr, Felix M.
AU - Stark, Regina
AU - Pellicci, Daniel G.
AU - Godfrey, Dale I.
AU - Belz, Gabrielle T.
AU - Pellegrini, Marc
AU - Gebhardt, Thomas
AU - Busslinger, Meinrad
AU - Shi, Wei
AU - Carbone, Francis R.
AU - Van Lier, René A.W.
AU - Kallies, Axel
AU - Van Gisbergen, Klaas P.J.M.
PY - 2016/4/22
Y1 - 2016/4/22
N2 - Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection.To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK cells, all of which share a common transcriptional program. Our results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations.
AB - Tissue-resident memory T (Trm) cells permanently localize to portals of pathogen entry, where they provide immediate protection against reinfection.To enforce tissue retention, Trm cells up-regulate CD69 and down-regulate molecules associated with tissue egress; however, a Trm-specific transcriptional regulator has not been identified. Here, we show that the transcription factor Hobit is specifically up-regulated in Trm cells and, together with related Blimp1, mediates the development of Trm cells in skin, gut, liver, and kidney in mice. The Hobit-Blimp1 transcriptional module is also required for other populations of tissue-resident lymphocytes, including natural killer T (NKT) cells and liver-resident NK cells, all of which share a common transcriptional program. Our results identify Hobit and Blimp1 as central regulators of this universal program that instructs tissue retention in diverse tissue-resident lymphocyte populations.
UR - https://www.scopus.com/pages/publications/84964887792
U2 - 10.1126/science.aad2035
DO - 10.1126/science.aad2035
M3 - Article
C2 - 27102484
AN - SCOPUS:84964887792
SN - 0036-8075
VL - 352
SP - 459
EP - 463
JO - Science
JF - Science
IS - 6284
ER -