HLA variation and disease

Calliope A. Dendrou, Jan Petersen, Jamie Rossjohn, Lars Fugger

Research output: Contribution to journalReview ArticleResearchpeer-review

258 Citations (Scopus)


Fifty years since the first description of an association between HLA and human disease, HLA molecules have proven to be central to physiology, protective immunity and deleterious, disease-causing autoimmune reactivity. Technological advances have enabled pivotal progress in the determination of the molecular mechanisms that underpin the association between HLA genetics and functional outcome. Here, we review our current understanding of HLA molecules as the fundamental platform for immune surveillance and responsiveness in health and disease. We evaluate the scope for personalized antigen-specific disease prevention, whereby harnessing HLA-ligand interactions for clinical benefit is becoming a realistic prospect.

Original languageEnglish
Pages (from-to)325-339
Number of pages15
JournalNature Reviews Immunology
Issue number5
Publication statusPublished - 2 Jan 2018


  • autoimmunity
  • genetic predisposition to disease
  • MHC

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