HLA-DP variation as additional risk factor in IDDM

S. Easteal, M. R.J. Kohonen-Corish, P. Zimmet, S. W. Serjeantson

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Abstract

A significant increase in the frequency of DPw3/6 alleles defined by restriction-fragment-length polymorphism is observed in insulin-dependent diabetes mellitus (IDDM) patients relative to healthy control subjects (34.6 vs. 10.5%, P < 0.009). Log-linear modeling demonstrates that this association is independent of HLA-DR3 and -DR4 and IDDM association and cannot be attributed to linkage disequilibrium between HLA-DP and -DR. The analysis also demonstrates an absence of interactive effects among the antigens in conferring IDDM susceptibility. The strength of the DPw3/6 association is not significantly less than that of either DR3 or DR4.

Original languageEnglish
Pages (from-to)855-857
Number of pages3
JournalDiabetes
Volume39
Issue number7
DOIs
Publication statusPublished - 1990
Externally publishedYes

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