HLA-DP variation as additional risk factor in IDDM

S. Easteal; M. R.J. Kohonen-Corish; P. Zimmet; S. W. Serjeantson

doi:10.2337/diab.39.7.855

HLA-DP variation as additional risk factor in IDDM

S. Easteal, M. R.J. Kohonen-Corish, P. Zimmet, S. W. Serjeantson

Research output: Contribution to journal › Article › Research › peer-review

28 Citations (Scopus)

Abstract

A significant increase in the frequency of DPw3/6 alleles defined by restriction-fragment-length polymorphism is observed in insulin-dependent diabetes mellitus (IDDM) patients relative to healthy control subjects (34.6 vs. 10.5%, P < 0.009). Log-linear modeling demonstrates that this association is independent of HLA-DR3 and -DR4 and IDDM association and cannot be attributed to linkage disequilibrium between HLA-DP and -DR. The analysis also demonstrates an absence of interactive effects among the antigens in conferring IDDM susceptibility. The strength of the DPw3/6 association is not significantly less than that of either DR3 or DR4.

Original language	English
Pages (from-to)	855-857
Number of pages	3
Journal	Diabetes
Volume	39
Issue number	7
DOIs	https://doi.org/10.2337/diab.39.7.855
Publication status	Published - 1990
Externally published	Yes

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title = "HLA-DP variation as additional risk factor in IDDM",

abstract = "A significant increase in the frequency of DPw3/6 alleles defined by restriction-fragment-length polymorphism is observed in insulin-dependent diabetes mellitus (IDDM) patients relative to healthy control subjects (34.6 vs. 10.5%, P < 0.009). Log-linear modeling demonstrates that this association is independent of HLA-DR3 and -DR4 and IDDM association and cannot be attributed to linkage disequilibrium between HLA-DP and -DR. The analysis also demonstrates an absence of interactive effects among the antigens in conferring IDDM susceptibility. The strength of the DPw3/6 association is not significantly less than that of either DR3 or DR4.",

author = "S. Easteal and Kohonen-Corish, {M. R.J.} and P. Zimmet and Serjeantson, {S. W.}",

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T1 - HLA-DP variation as additional risk factor in IDDM

AU - Easteal, S.

AU - Kohonen-Corish, M. R.J.

AU - Zimmet, P.

AU - Serjeantson, S. W.

PY - 1990

Y1 - 1990

N2 - A significant increase in the frequency of DPw3/6 alleles defined by restriction-fragment-length polymorphism is observed in insulin-dependent diabetes mellitus (IDDM) patients relative to healthy control subjects (34.6 vs. 10.5%, P < 0.009). Log-linear modeling demonstrates that this association is independent of HLA-DR3 and -DR4 and IDDM association and cannot be attributed to linkage disequilibrium between HLA-DP and -DR. The analysis also demonstrates an absence of interactive effects among the antigens in conferring IDDM susceptibility. The strength of the DPw3/6 association is not significantly less than that of either DR3 or DR4.

AB - A significant increase in the frequency of DPw3/6 alleles defined by restriction-fragment-length polymorphism is observed in insulin-dependent diabetes mellitus (IDDM) patients relative to healthy control subjects (34.6 vs. 10.5%, P < 0.009). Log-linear modeling demonstrates that this association is independent of HLA-DR3 and -DR4 and IDDM association and cannot be attributed to linkage disequilibrium between HLA-DP and -DR. The analysis also demonstrates an absence of interactive effects among the antigens in conferring IDDM susceptibility. The strength of the DPw3/6 association is not significantly less than that of either DR3 or DR4.

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DO - 10.2337/diab.39.7.855

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SP - 855

EP - 857

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 7

ER -

HLA-DP variation as additional risk factor in IDDM

Abstract

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