HLA and schizophrenia: Refutation of reported associations with A9 (A23/A24), DR4, and DQβ1 *0602

Stephanie Gibson, Ziarih Hawi, Richard E. Straub, Dermot Walsh, Kenneth S. Kendler, Michael Gill

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The aim of this study was to test previous hypotheses of association between schizophrenia and human leukocyte antigen (HLA) specificities A9 (A23/24), DR4, and allele DQβ1*0602. Using sequence-specific oligonucleotide probes, 256 familial schizophrenic patients and 261 unrelated controls were genotyped at polymorphisms for HLAA, DRβ1, and DQβ1 loci. No significant (p <0.05) differences in the allele frequencies between schizophrenics and controls were found, either when examining the sample as a whole or when subdivided by clinical subtype or gender. The present data do not support association between these HLA specificities and schizophrenia, and our review of previous studies suggests that reported associations may well be false positive results.

Original languageEnglish
Pages (from-to)416-421
Number of pages6
JournalAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics
Issue number4
Publication statusPublished - 20 Aug 1999
Externally publishedYes


  • Association
  • Genetics
  • Human leukocyte antigens (HLA)
  • Schizophrenia

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