HLA and Drug Hypersensitivity

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Abstract

Adverse drug reactions (ADRs) place a large economic strain on our health care system and prevent the use of key medications by many individuals. A subset of ADRs show evidence of mediation by the human leukocyte antigen (HLA) molecules, and numerous associations between specific ADRs and particular HLA alleles or subgroups have been identified. Here we discuss the current models for interaction of small molecule drugs with the HLA and the supporting evidence in the context of antigen-processing and presentation.

Original languageEnglish
Title of host publicationMolecular Immunology
PublisherAcademic Press
Pages310-317
Number of pages8
Volume2
ISBN (Print)9780080921525
DOIs
Publication statusPublished - 27 Apr 2016

Keywords

  • Abacavir
  • Adverse drug reactions
  • Allopurinol
  • Altered repertoire model
  • Carbamazepine
  • Drug-induced liver injury
  • Drug-induced skin injury
  • Hapten concept
  • Human leukocyte antigen
  • Hypersensitivity
  • Hypersensitivity syndrome
  • Maculopapular exanthema
  • P.i. concept
  • Stevens-Johnson syndrome/toxic epidermal necrolysis

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