HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation

Jason V Baker, Kathleen Brummel-Ziedins, Jacqueline Neuhaus, Daniel Duprez, Nathan Cummins, David Dalmau, Jack DeHovitz, Clara Lehmann, Ann Sullivan, Ian John Woolley, Lewis H Kuller, James D Neaton, Russell Tracy

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

Background HIV infection leads to activation of coagulation, which may increase the risk for atherosclerosis and venous thromboembolic disease. We hypothesized that HIV replication increases coagulation potentially through alterations in extrinsic pathway factors. Methods and Results Extrinsic pathway factors were measured among a subset of HIV participants from the Strategies for Management of Anti-Retroviral Therapy (SMART) trial. Thrombin generation was estimated using validated computational modeling based on factor composition. We characterized the effect of antiretroviral therapy (ART) treatment versus the untreated state (HIV replication) via 3 separate analyses: (1) a cross-sectional comparison of those on and off ART (n=717); (2) a randomized comparison of deferring versus starting ART (n=217); and (3) a randomized comparison of stopping versus continuing ART (n=500). Compared with viral suppression, HIV replication consistently showed short-term increases in some procoagulants (eg, 15 to 23 higher FVIII; P
Original languageEnglish
Pages (from-to)1 - 13
Number of pages13
JournalAmerican Heart Association. Journal. Cardiovascular and Cerebrovascular Disease
Volume2
Issue number4 (Art. No.: e000264)
DOIs
Publication statusPublished - 2013

Cite this

Baker, Jason V ; Brummel-Ziedins, Kathleen ; Neuhaus, Jacqueline ; Duprez, Daniel ; Cummins, Nathan ; Dalmau, David ; DeHovitz, Jack ; Lehmann, Clara ; Sullivan, Ann ; Woolley, Ian John ; Kuller, Lewis H ; Neaton, James D ; Tracy, Russell. / HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation. In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 2013 ; Vol. 2, No. 4 (Art. No.: e000264). pp. 1 - 13.
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abstract = "Background HIV infection leads to activation of coagulation, which may increase the risk for atherosclerosis and venous thromboembolic disease. We hypothesized that HIV replication increases coagulation potentially through alterations in extrinsic pathway factors. Methods and Results Extrinsic pathway factors were measured among a subset of HIV participants from the Strategies for Management of Anti-Retroviral Therapy (SMART) trial. Thrombin generation was estimated using validated computational modeling based on factor composition. We characterized the effect of antiretroviral therapy (ART) treatment versus the untreated state (HIV replication) via 3 separate analyses: (1) a cross-sectional comparison of those on and off ART (n=717); (2) a randomized comparison of deferring versus starting ART (n=217); and (3) a randomized comparison of stopping versus continuing ART (n=500). Compared with viral suppression, HIV replication consistently showed short-term increases in some procoagulants (eg, 15 to 23 higher FVIII; P",
author = "Baker, {Jason V} and Kathleen Brummel-Ziedins and Jacqueline Neuhaus and Daniel Duprez and Nathan Cummins and David Dalmau and Jack DeHovitz and Clara Lehmann and Ann Sullivan and Woolley, {Ian John} and Kuller, {Lewis H} and Neaton, {James D} and Russell Tracy",
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language = "English",
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Baker, JV, Brummel-Ziedins, K, Neuhaus, J, Duprez, D, Cummins, N, Dalmau, D, DeHovitz, J, Lehmann, C, Sullivan, A, Woolley, IJ, Kuller, LH, Neaton, JD & Tracy, R 2013, 'HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation', American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, vol. 2, no. 4 (Art. No.: e000264), pp. 1 - 13. https://doi.org/10.1161/JAHA.113.000264

HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation. / Baker, Jason V; Brummel-Ziedins, Kathleen; Neuhaus, Jacqueline; Duprez, Daniel; Cummins, Nathan; Dalmau, David; DeHovitz, Jack; Lehmann, Clara; Sullivan, Ann; Woolley, Ian John; Kuller, Lewis H; Neaton, James D; Tracy, Russell.

In: American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease, Vol. 2, No. 4 (Art. No.: e000264), 2013, p. 1 - 13.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation

AU - Baker, Jason V

AU - Brummel-Ziedins, Kathleen

AU - Neuhaus, Jacqueline

AU - Duprez, Daniel

AU - Cummins, Nathan

AU - Dalmau, David

AU - DeHovitz, Jack

AU - Lehmann, Clara

AU - Sullivan, Ann

AU - Woolley, Ian John

AU - Kuller, Lewis H

AU - Neaton, James D

AU - Tracy, Russell

PY - 2013

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N2 - Background HIV infection leads to activation of coagulation, which may increase the risk for atherosclerosis and venous thromboembolic disease. We hypothesized that HIV replication increases coagulation potentially through alterations in extrinsic pathway factors. Methods and Results Extrinsic pathway factors were measured among a subset of HIV participants from the Strategies for Management of Anti-Retroviral Therapy (SMART) trial. Thrombin generation was estimated using validated computational modeling based on factor composition. We characterized the effect of antiretroviral therapy (ART) treatment versus the untreated state (HIV replication) via 3 separate analyses: (1) a cross-sectional comparison of those on and off ART (n=717); (2) a randomized comparison of deferring versus starting ART (n=217); and (3) a randomized comparison of stopping versus continuing ART (n=500). Compared with viral suppression, HIV replication consistently showed short-term increases in some procoagulants (eg, 15 to 23 higher FVIII; P

AB - Background HIV infection leads to activation of coagulation, which may increase the risk for atherosclerosis and venous thromboembolic disease. We hypothesized that HIV replication increases coagulation potentially through alterations in extrinsic pathway factors. Methods and Results Extrinsic pathway factors were measured among a subset of HIV participants from the Strategies for Management of Anti-Retroviral Therapy (SMART) trial. Thrombin generation was estimated using validated computational modeling based on factor composition. We characterized the effect of antiretroviral therapy (ART) treatment versus the untreated state (HIV replication) via 3 separate analyses: (1) a cross-sectional comparison of those on and off ART (n=717); (2) a randomized comparison of deferring versus starting ART (n=217); and (3) a randomized comparison of stopping versus continuing ART (n=500). Compared with viral suppression, HIV replication consistently showed short-term increases in some procoagulants (eg, 15 to 23 higher FVIII; P

UR - http://www.ncbi.nlm.nih.gov/pubmed/23896681

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DO - 10.1161/JAHA.113.000264

M3 - Article

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JO - American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease

JF - American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease

SN - 2047-9980

IS - 4 (Art. No.: e000264)

ER -