HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation

Jason V Baker; Kathleen Brummel-Ziedins; Jacqueline Neuhaus; Daniel Duprez; Nathan Cummins; David Dalmau; Jack DeHovitz; Clara Lehmann; Ann Sullivan; Ian John Woolley; Lewis H Kuller; James D Neaton; Russell Tracy

doi:10.1161/JAHA.113.000264

HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation

Jason V Baker, Kathleen Brummel-Ziedins, Jacqueline Neuhaus, Daniel Duprez, Nathan Cummins, David Dalmau, Jack DeHovitz, Clara Lehmann, Ann Sullivan, Ian John Woolley, Lewis H Kuller, James D Neaton, Russell Tracy

Infectious Diseases

Research output: Contribution to journal › Article › Research › peer-review

55 Citations (Scopus)

Abstract

Background HIV infection leads to activation of coagulation, which may increase the risk for atherosclerosis and venous thromboembolic disease. We hypothesized that HIV replication increases coagulation potentially through alterations in extrinsic pathway factors. Methods and Results Extrinsic pathway factors were measured among a subset of HIV participants from the Strategies for Management of Anti-Retroviral Therapy (SMART) trial. Thrombin generation was estimated using validated computational modeling based on factor composition. We characterized the effect of antiretroviral therapy (ART) treatment versus the untreated state (HIV replication) via 3 separate analyses: (1) a cross-sectional comparison of those on and off ART (n=717); (2) a randomized comparison of deferring versus starting ART (n=217); and (3) a randomized comparison of stopping versus continuing ART (n=500). Compared with viral suppression, HIV replication consistently showed short-term increases in some procoagulants (eg, 15 to 23 higher FVIII; P

Original language	English
Pages (from-to)	1 - 13
Number of pages	13
Journal	Journal of the American Heart Association
Volume	2
Issue number	4 (Art. No.: e000264)
DOIs	https://doi.org/10.1161/JAHA.113.000264
Publication status	Published - 2013

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Baker, J. V., Brummel-Ziedins, K., Neuhaus, J., Duprez, D., Cummins, N., Dalmau, D., DeHovitz, J., Lehmann, C., Sullivan, A., Woolley, I. J., Kuller, L. H., Neaton, J. D., & Tracy, R. (2013). HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation. Journal of the American Heart Association, 2(4 (Art. No.: e000264)), 1 - 13. https://doi.org/10.1161/JAHA.113.000264

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title = "HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation",

abstract = "Background HIV infection leads to activation of coagulation, which may increase the risk for atherosclerosis and venous thromboembolic disease. We hypothesized that HIV replication increases coagulation potentially through alterations in extrinsic pathway factors. Methods and Results Extrinsic pathway factors were measured among a subset of HIV participants from the Strategies for Management of Anti-Retroviral Therapy (SMART) trial. Thrombin generation was estimated using validated computational modeling based on factor composition. We characterized the effect of antiretroviral therapy (ART) treatment versus the untreated state (HIV replication) via 3 separate analyses: (1) a cross-sectional comparison of those on and off ART (n=717); (2) a randomized comparison of deferring versus starting ART (n=217); and (3) a randomized comparison of stopping versus continuing ART (n=500). Compared with viral suppression, HIV replication consistently showed short-term increases in some procoagulants (eg, 15 to 23 higher FVIII; P",

author = "Baker, {Jason V} and Kathleen Brummel-Ziedins and Jacqueline Neuhaus and Daniel Duprez and Nathan Cummins and David Dalmau and Jack DeHovitz and Clara Lehmann and Ann Sullivan and Woolley, {Ian John} and Kuller, {Lewis H} and Neaton, {James D} and Russell Tracy",

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doi = "10.1161/JAHA.113.000264",

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Baker, JV, Brummel-Ziedins, K, Neuhaus, J, Duprez, D, Cummins, N, Dalmau, D, DeHovitz, J, Lehmann, C, Sullivan, A, Woolley, IJ, Kuller, LH, Neaton, JD & Tracy, R 2013, 'HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation', Journal of the American Heart Association, vol. 2, no. 4 (Art. No.: e000264), pp. 1 - 13. https://doi.org/10.1161/JAHA.113.000264

TY - JOUR

T1 - HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation

AU - Baker, Jason V

AU - Brummel-Ziedins, Kathleen

AU - Neuhaus, Jacqueline

AU - Duprez, Daniel

AU - Cummins, Nathan

AU - Dalmau, David

AU - DeHovitz, Jack

AU - Lehmann, Clara

AU - Sullivan, Ann

AU - Woolley, Ian John

AU - Kuller, Lewis H

AU - Neaton, James D

AU - Tracy, Russell

PY - 2013

Y1 - 2013

N2 - Background HIV infection leads to activation of coagulation, which may increase the risk for atherosclerosis and venous thromboembolic disease. We hypothesized that HIV replication increases coagulation potentially through alterations in extrinsic pathway factors. Methods and Results Extrinsic pathway factors were measured among a subset of HIV participants from the Strategies for Management of Anti-Retroviral Therapy (SMART) trial. Thrombin generation was estimated using validated computational modeling based on factor composition. We characterized the effect of antiretroviral therapy (ART) treatment versus the untreated state (HIV replication) via 3 separate analyses: (1) a cross-sectional comparison of those on and off ART (n=717); (2) a randomized comparison of deferring versus starting ART (n=217); and (3) a randomized comparison of stopping versus continuing ART (n=500). Compared with viral suppression, HIV replication consistently showed short-term increases in some procoagulants (eg, 15 to 23 higher FVIII; P

AB - Background HIV infection leads to activation of coagulation, which may increase the risk for atherosclerosis and venous thromboembolic disease. We hypothesized that HIV replication increases coagulation potentially through alterations in extrinsic pathway factors. Methods and Results Extrinsic pathway factors were measured among a subset of HIV participants from the Strategies for Management of Anti-Retroviral Therapy (SMART) trial. Thrombin generation was estimated using validated computational modeling based on factor composition. We characterized the effect of antiretroviral therapy (ART) treatment versus the untreated state (HIV replication) via 3 separate analyses: (1) a cross-sectional comparison of those on and off ART (n=717); (2) a randomized comparison of deferring versus starting ART (n=217); and (3) a randomized comparison of stopping versus continuing ART (n=500). Compared with viral suppression, HIV replication consistently showed short-term increases in some procoagulants (eg, 15 to 23 higher FVIII; P

UR - http://www.ncbi.nlm.nih.gov/pubmed/23896681

U2 - 10.1161/JAHA.113.000264

DO - 10.1161/JAHA.113.000264

M3 - Article

VL - 2

SP - 1

EP - 13

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 4 (Art. No.: e000264)

ER -

HIV replication alters the composition of extrinsic pathway coagulation factors and increases thrombin generation

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