TY - JOUR
T1 - HIV infection and high density lipoprotein metabolism
AU - Rose, Honor May
AU - Hoy, Jennifer F
AU - Woolley, Ian John
AU - Tchoua, Urbain
AU - Bukrinsky, Michael
AU - Dart, Anthony M
AU - Sviridov, Dimitri
PY - 2008
Y1 - 2008
N2 - HIV infection and its treatment are associated with dyslipidemia, including hypoalphalipoproteinemia, and increased risk of cardiovascular disease. Parameters of HDL metabolism in HIV-positive patients were investigated in a cross-sectional study. The following groups of subjects were selected: (i) 25 treatment-na??ve HIV-infected patients or HIV-infected patients on long therapy break, (ii) 28 HIV-infected patients currently treated with protease inhibitors, and (iii) 33 HIV-negative subjects. Compared to the HIV-negative group, all groups of HIV-infected patients were characterized by significantly elevated triglyceride and apolipoprotein B levels, mass and activity of lecithin cholesterol acyl transferase and cholesteryl ester transfer protein (p <0.01). Total and LDL cholesterol was lower in treatment-na??ve HIV-infected group only. HDL cholesterol and preI?1-HDL were significantly lower in all HIV-infected groups (p <0.05), while mean levels of apolipoprotein Aa??I (apoAa??I) and ability of plasma to promote cholesterol efflux were similar in all groups. We found a positive correlation between apoAa??I and levels of CD4+ cells (r2 = 0.3, p <0.001). Plasma level of phospholipid transfer protein was reduced in the group on antiretroviral therapy. Taken together these results suggest that HIV infection is associated with modified HDL metabolism re-directing cholesterol to the apoB-containing lipoproteins and likely reducing the functionality of reverse cholesterol transport.
AB - HIV infection and its treatment are associated with dyslipidemia, including hypoalphalipoproteinemia, and increased risk of cardiovascular disease. Parameters of HDL metabolism in HIV-positive patients were investigated in a cross-sectional study. The following groups of subjects were selected: (i) 25 treatment-na??ve HIV-infected patients or HIV-infected patients on long therapy break, (ii) 28 HIV-infected patients currently treated with protease inhibitors, and (iii) 33 HIV-negative subjects. Compared to the HIV-negative group, all groups of HIV-infected patients were characterized by significantly elevated triglyceride and apolipoprotein B levels, mass and activity of lecithin cholesterol acyl transferase and cholesteryl ester transfer protein (p <0.01). Total and LDL cholesterol was lower in treatment-na??ve HIV-infected group only. HDL cholesterol and preI?1-HDL were significantly lower in all HIV-infected groups (p <0.05), while mean levels of apolipoprotein Aa??I (apoAa??I) and ability of plasma to promote cholesterol efflux were similar in all groups. We found a positive correlation between apoAa??I and levels of CD4+ cells (r2 = 0.3, p <0.001). Plasma level of phospholipid transfer protein was reduced in the group on antiretroviral therapy. Taken together these results suggest that HIV infection is associated with modified HDL metabolism re-directing cholesterol to the apoB-containing lipoproteins and likely reducing the functionality of reverse cholesterol transport.
UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T12-4R8PNP8-3&_user=542840&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000027659&_vers
U2 - 10.1016/j.atherosclerosis.2007.10.018
DO - 10.1016/j.atherosclerosis.2007.10.018
M3 - Article
VL - 199
SP - 79
EP - 86
JO - Atherosclerosis
JF - Atherosclerosis
SN - 0021-9150
IS - 1
ER -