HIV infection and high density lipoprotein metabolism

HIV infection and its treatment are associated with dyslipidemia, including hypoalphalipoproteinemia, and increased risk of cardiovascular disease. Parameters of HDL metabolism in HIV-positive patients were investigated in a cross-sectional study. The following groups of subjects were selected: (i) 25 treatment-na??ve HIV-infected patients or HIV-infected patients on long therapy break, (ii) 28 HIV-infected patients currently treated with protease inhibitors, and (iii) 33 HIV-negative subjects. Compared to the HIV-negative group, all groups of HIV-infected patients were characterized by significantly elevated triglyceride and apolipoprotein B levels, mass and activity of lecithin cholesterol acyl transferase and cholesteryl ester transfer protein (p <0.01). Total and LDL cholesterol was lower in treatment-na??ve HIV-infected group only. HDL cholesterol and preI?1-HDL were significantly lower in all HIV-infected groups (p <0.05), while mean levels of apolipoprotein Aa??I (apoAa??I) and ability of plasma to promote cholesterol efflux were similar in all groups. We found a positive correlation between apoAa??I and levels of CD4+ cells (r2 = 0.3, p <0.001). Plasma level of phospholipid transfer protein was reduced in the group on antiretroviral therapy. Taken together these results suggest that HIV infection is associated with modified HDL metabolism re-directing cholesterol to the apoB-containing lipoproteins and likely reducing the functionality of reverse cholesterol transport.