HIV and co-infections

Christina Catherine Chang, Megan Crane, Jingling Zhou, Michael Mina, Jeffrey Post, Barbara Cameron, Andrew Lloyd, Anthony Jaworowski, Martyn French, Sharon Ruth Lewin

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Abstract

Despite significant reductions in morbidity and mortality secondary to availability of effective combination anti-retroviral therapy (cART), human immunodeficiency virus (HIV) infection still accounts for 1.5 million deaths annually. The majority of deaths occur in sub-Saharan Africa where rates of opportunistic co-infections are disproportionately high. In this review, we discuss the immunopathogenesis of five common infections that cause significant morbidity in HIV-infected patients globally. These include co-infection with Mycobacterium tuberculosis, Cryptococcus neoformans, hepatitis B virus, hepatitis C virus, and Plasmodium falciparum. Specifically, we review the natural history of each co-infection in the setting of HIV, the specific immune defects induced by HIV, the effects of cART on the immune response to the co-infection, the pathogenesis of immune restoration disease (IRD) associated with each infection, and advances in the areas of prevention of each co-infection via vaccination. Finally, we discuss the opportunities and gaps in knowledge for future research.
Original languageEnglish
Pages (from-to)114 - 142
Number of pages29
JournalImmunological Reviews
Volume254
Issue number1
DOIs
Publication statusPublished - 2013

Cite this

Chang, C. C., Crane, M., Zhou, J., Mina, M., Post, J., Cameron, B., ... Lewin, S. R. (2013). HIV and co-infections. Immunological Reviews, 254(1), 114 - 142. https://doi.org/10.1111/imr.12063
Chang, Christina Catherine ; Crane, Megan ; Zhou, Jingling ; Mina, Michael ; Post, Jeffrey ; Cameron, Barbara ; Lloyd, Andrew ; Jaworowski, Anthony ; French, Martyn ; Lewin, Sharon Ruth. / HIV and co-infections. In: Immunological Reviews. 2013 ; Vol. 254, No. 1. pp. 114 - 142.
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Chang, CC, Crane, M, Zhou, J, Mina, M, Post, J, Cameron, B, Lloyd, A, Jaworowski, A, French, M & Lewin, SR 2013, 'HIV and co-infections', Immunological Reviews, vol. 254, no. 1, pp. 114 - 142. https://doi.org/10.1111/imr.12063

HIV and co-infections. / Chang, Christina Catherine; Crane, Megan; Zhou, Jingling; Mina, Michael; Post, Jeffrey; Cameron, Barbara; Lloyd, Andrew; Jaworowski, Anthony; French, Martyn; Lewin, Sharon Ruth.

In: Immunological Reviews, Vol. 254, No. 1, 2013, p. 114 - 142.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Chang, Christina Catherine

AU - Crane, Megan

AU - Zhou, Jingling

AU - Mina, Michael

AU - Post, Jeffrey

AU - Cameron, Barbara

AU - Lloyd, Andrew

AU - Jaworowski, Anthony

AU - French, Martyn

AU - Lewin, Sharon Ruth

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Chang CC, Crane M, Zhou J, Mina M, Post J, Cameron B et al. HIV and co-infections. Immunological Reviews. 2013;254(1):114 - 142. https://doi.org/10.1111/imr.12063