HIV and age do not substantially interact in HIV-associated neurocognitive impairment

Lucette A Cysique; Paul M Maruff; Margaret P Bain; Edwina Wright; Bruce J Brew

HIV and age do not substantially interact in HIV-associated neurocognitive impairment

Lucette A Cysique, Paul M Maruff, Margaret P Bain, Edwina Wright, Bruce J Brew

Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

34 Citations (Scopus)

Abstract

The authors investigated the combined age and HIV effects on cognitive functions in 146 individuals, 116 of whom had HIV infection. Fortytwo percent had HIV-associated neurocognitive disorder, and all were receiving highly active antiretroviral therapy. Using linear and nonlinear regression modeling, the authors found only a trending effect of the quadratic term HIV status age, both including dementia cases (p 0.12) and excluding dementia cases (p 0.06). Our results suggest that either this early-2000 cohort is not old enough to detect a clear interactive age and HIV effect or that there may be a survivor bias for individuals with longterm infection. Further longitudinal studies are warranted

Original language	English
Pages (from-to)	83 - 89
Number of pages	7
Journal	The Journal of Neuropsychiatry and Clinical Neurosciences
Volume	23
Issue number	1
Publication status	Published - 2011

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Cite this

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title = "HIV and age do not substantially interact in HIV-associated neurocognitive impairment",

abstract = "The authors investigated the combined age and HIV effects on cognitive functions in 146 individuals, 116 of whom had HIV infection. Fortytwo percent had HIV-associated neurocognitive disorder, and all were receiving highly active antiretroviral therapy. Using linear and nonlinear regression modeling, the authors found only a trending effect of the quadratic term HIV status age, both including dementia cases (p 0.12) and excluding dementia cases (p 0.06). Our results suggest that either this early-2000 cohort is not old enough to detect a clear interactive age and HIV effect or that there may be a survivor bias for individuals with longterm infection. Further longitudinal studies are warranted",

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AU - Cysique, Lucette A

AU - Maruff, Paul M

AU - Bain, Margaret P

AU - Wright, Edwina

AU - Brew, Bruce J

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N2 - The authors investigated the combined age and HIV effects on cognitive functions in 146 individuals, 116 of whom had HIV infection. Fortytwo percent had HIV-associated neurocognitive disorder, and all were receiving highly active antiretroviral therapy. Using linear and nonlinear regression modeling, the authors found only a trending effect of the quadratic term HIV status age, both including dementia cases (p 0.12) and excluding dementia cases (p 0.06). Our results suggest that either this early-2000 cohort is not old enough to detect a clear interactive age and HIV effect or that there may be a survivor bias for individuals with longterm infection. Further longitudinal studies are warranted

AB - The authors investigated the combined age and HIV effects on cognitive functions in 146 individuals, 116 of whom had HIV infection. Fortytwo percent had HIV-associated neurocognitive disorder, and all were receiving highly active antiretroviral therapy. Using linear and nonlinear regression modeling, the authors found only a trending effect of the quadratic term HIV status age, both including dementia cases (p 0.12) and excluding dementia cases (p 0.06). Our results suggest that either this early-2000 cohort is not old enough to detect a clear interactive age and HIV effect or that there may be a survivor bias for individuals with longterm infection. Further longitudinal studies are warranted

UR - http://neuro.psychiatryonline.org/data/Journals/NP/4317/jnp00111000083.pdf

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ER -

HIV and age do not substantially interact in HIV-associated neurocognitive impairment

Abstract

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