HIV and age do not substantially interact in HIV-associated neurocognitive impairment

Lucette A Cysique, Paul M Maruff, Margaret P Bain, Edwina Wright, Bruce J Brew

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31 Citations (Scopus)


The authors investigated the combined age and HIV effects on cognitive functions in 146 individuals, 116 of whom had HIV infection. Fortytwo percent had HIV-associated neurocognitive disorder, and all were receiving highly active antiretroviral therapy. Using linear and nonlinear regression modeling, the authors found only a trending effect of the quadratic term HIV status age, both including dementia cases (p 0.12) and excluding dementia cases (p 0.06). Our results suggest that either this early-2000 cohort is not old enough to detect a clear interactive age and HIV effect or that there may be a survivor bias for individuals with longterm infection. Further longitudinal studies are warranted
Original languageEnglish
Pages (from-to)83 - 89
Number of pages7
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number1
Publication statusPublished - 2011

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