HIV-1 envelope-receptor interactions required for macrophage infection and implications for current HIV-1 cure strategies

Paul R Gorry, Nicholas Francella, Sharon Ruth Lewin, Ronald G Collman

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21 Citations (Scopus)


Myeloid cells residing in the CNS and lymphoid tissues are targets for productive HIV-1 replication, and their infection contributes to the pathological manifestations of HIV-1 infection. The Envs can adopt altered configurations to overcome entry restrictions in macrophages via a more efficient and/or altered mechanism of engagement with cellular receptors. This review highlights evidence supporting an important role for macrophages in HIV-1 pathogenesis and persistence, which need to be considered for strategies aimed at achieving a functional or sterilizing cure. We also highlight that the molecular mechanisms underlying HIV-1 tropism for macrophages are complex, involving enhanced and/or altered interactions with CD4, CCR5, and/or CXCR4, and that the nature of these interactions may depend on the anatomical location of the virus.
Original languageEnglish
Pages (from-to)71 - 81
Number of pages11
JournalJournal of leukocyte biology
Issue number1
Publication statusPublished - 2014

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