HIV-1 CRF01-AE strain is associated with faster HIV/AIDS progression in Jiangsu Province, China

Minjie Chu, Wuhong Zhang, Xuan Zhang, Wenjie Jiang, Xiping Huan, Xiaojun Meng, Bowen Zhu, Yue Yang, Yusha Tao, Tian Tian, Yihua Lu, Liying Jiang, Lei Zhang, Xun Zhuang

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The goal of this study was to assess risk factors associated with HIV/AIDS progression. Between May 2007 and December 2014, 114 subjects were enrolled in Wuxi City and examined every 6 months. The pol gene sequence was amplified to ascertain the HIV-1 subtype. A Cox proportional hazards regression model was used to estimate the factors associated with HIV/AIDS progression. The median follow-up time for all 114 subjects was 26.70 months (IQR: 18.50-41.47), while the median progression time of the 38 progressed subjects was 24.80 months (IQR: 14.13-34.38). Overall, the CRF01-AE subtype was correlated with a significant risk of accelerated progression compared to non-CRF01-AE subtypes (HR = 3.14, 95%CI: 1.39-7.08, P = 0.006). In addition, a lower CD4 count (350-499) at baseline was associated with a risk of accelerated HIV/AIDS progression compared to higher CD4 count (≥500) (HR = 4.38, 95%CI: 1.95-9.82, P < 0.001). Furthermore, interaction analyses showed that HIV-1 subtypes interacted multiplicatively with transmission routes or CD4 count at baseline to contribute to HIV/AIDS progression (P = 0.023 and P < 0.001, respectively). In conclusion, the CRF01-AE subtype and a lower CD4 count at baseline tend to be associated with the faster progression of HIV/AIDS. Understanding the factors affecting HIV/AIDS progression is crucial for developing personalized management and clinical counselling strategies.

Original languageEnglish
Article number1570
Number of pages8
JournalScientific Reports
Issue number1
Publication statusPublished - 1 Dec 2017

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