Abstract
The pathogenesis of clostridial myonecrosis or gas gangrene involves an interruption to the blood supply to the infected tissues, often via a traumatic wound, anaerobic growth of the infecting clostridial cells, the production of extracellular toxins, and toxin-mediated cell and tissue damage. This review focuses on host-pathogen interactions in Clostridium perfringens-mediated and Clostridium septicum-mediated myonecrosis. The major toxins involved are C. perfringens α-toxin, which has phospholipase C and sphingomyelinase activity, and C. septicum α-toxin, a β-pore-forming toxin that belongs to the aerolysin family. Although these toxins are cytotoxic, their effects on host cells are quite complex, with a range of intracellular cell signaling pathways induced by their action on host cell membranes.
| Original language | English |
|---|---|
| Article number | GPP3-0024-2018 |
| Number of pages | 17 |
| Journal | Microbiology spectrum |
| Volume | 7 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 2019 |
Cite this
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Histotoxic clostridial infections. / Nagahama, Masahiro; Takehara, Masaya; Rood, Julian I.
In: Microbiology spectrum, Vol. 7, No. 4, GPP3-0024-2018, 07.2019.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Histotoxic clostridial infections
AU - Nagahama, Masahiro
AU - Takehara, Masaya
AU - Rood, Julian I.
PY - 2019/7
Y1 - 2019/7
N2 - The pathogenesis of clostridial myonecrosis or gas gangrene involves an interruption to the blood supply to the infected tissues, often via a traumatic wound, anaerobic growth of the infecting clostridial cells, the production of extracellular toxins, and toxin-mediated cell and tissue damage. This review focuses on host-pathogen interactions in Clostridium perfringens-mediated and Clostridium septicum-mediated myonecrosis. The major toxins involved are C. perfringens α-toxin, which has phospholipase C and sphingomyelinase activity, and C. septicum α-toxin, a β-pore-forming toxin that belongs to the aerolysin family. Although these toxins are cytotoxic, their effects on host cells are quite complex, with a range of intracellular cell signaling pathways induced by their action on host cell membranes.
AB - The pathogenesis of clostridial myonecrosis or gas gangrene involves an interruption to the blood supply to the infected tissues, often via a traumatic wound, anaerobic growth of the infecting clostridial cells, the production of extracellular toxins, and toxin-mediated cell and tissue damage. This review focuses on host-pathogen interactions in Clostridium perfringens-mediated and Clostridium septicum-mediated myonecrosis. The major toxins involved are C. perfringens α-toxin, which has phospholipase C and sphingomyelinase activity, and C. septicum α-toxin, a β-pore-forming toxin that belongs to the aerolysin family. Although these toxins are cytotoxic, their effects on host cells are quite complex, with a range of intracellular cell signaling pathways induced by their action on host cell membranes.
UR - http://www.scopus.com/inward/record.url?scp=85070470562&partnerID=8YFLogxK
U2 - 10.1128/microbiolspec.GPP3-0024-2018
DO - 10.1128/microbiolspec.GPP3-0024-2018
M3 - Article
VL - 7
JO - Microbiology spectrum
JF - Microbiology spectrum
SN - 2165-0497
IS - 4
M1 - GPP3-0024-2018
ER -