Histotoxic clostridial infections

Masahiro Nagahama, Masaya Takehara, Julian I. Rood

Research output: Contribution to journalArticleResearchpeer-review

Abstract

The pathogenesis of clostridial myonecrosis or gas gangrene involves an interruption to the blood supply to the infected tissues, often via a traumatic wound, anaerobic growth of the infecting clostridial cells, the production of extracellular toxins, and toxin-mediated cell and tissue damage. This review focuses on host-pathogen interactions in Clostridium perfringens-mediated and Clostridium septicum-mediated myonecrosis. The major toxins involved are C. perfringens α-toxin, which has phospholipase C and sphingomyelinase activity, and C. septicum α-toxin, a β-pore-forming toxin that belongs to the aerolysin family. Although these toxins are cytotoxic, their effects on host cells are quite complex, with a range of intracellular cell signaling pathways induced by their action on host cell membranes.

Original languageEnglish
Article numberGPP3-0024-2018
Number of pages17
JournalMicrobiology spectrum
Volume7
Issue number4
DOIs
Publication statusPublished - Jul 2019

Cite this

Nagahama, Masahiro ; Takehara, Masaya ; Rood, Julian I. / Histotoxic clostridial infections. In: Microbiology spectrum. 2019 ; Vol. 7, No. 4.
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Histotoxic clostridial infections. / Nagahama, Masahiro; Takehara, Masaya; Rood, Julian I.

In: Microbiology spectrum, Vol. 7, No. 4, GPP3-0024-2018, 07.2019.

Research output: Contribution to journalArticleResearchpeer-review

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