Abstract
DNA double strand breaks need to be repaired in an organized fashion to preserve genomic integrity. In the organization of faithful repair, histone ubiquitination plays a crucial role. Recent findings suggest an integrated model for DNA repair regulation through site-specific histone ubiquitination and crosstalk to other posttranslational modifications. Here we discuss how site-specific histone ubiquitination is achieved on a molecular level and how different multi-protein complexes work together to integrate different histone ubiquitination states. We propose a model where site-specific H2A ubiquitination organizes the spatio-temporal recruitment of DNA repair factors which will ultimately contribute to DNA repair pathway choice between homologous recombination and non-homologous end joining.
Original language | English |
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Pages (from-to) | 92-101 |
Number of pages | 10 |
Journal | DNA Repair |
Volume | 56 |
DOIs | |
Publication status | Published - 1 Aug 2017 |
Externally published | Yes |
Keywords
- BRCA1/BARD1
- BRE1
- DNA damage response
- Histone ubiquitination
- PRC1
- RNF168