Histone ubiquitination in the DNA damage response

Michael Uckelmann, Titia K. Sixma

Research output: Contribution to journalReview ArticleResearchpeer-review

40 Citations (Scopus)

Abstract

DNA double strand breaks need to be repaired in an organized fashion to preserve genomic integrity. In the organization of faithful repair, histone ubiquitination plays a crucial role. Recent findings suggest an integrated model for DNA repair regulation through site-specific histone ubiquitination and crosstalk to other posttranslational modifications. Here we discuss how site-specific histone ubiquitination is achieved on a molecular level and how different multi-protein complexes work together to integrate different histone ubiquitination states. We propose a model where site-specific H2A ubiquitination organizes the spatio-temporal recruitment of DNA repair factors which will ultimately contribute to DNA repair pathway choice between homologous recombination and non-homologous end joining.

Original languageEnglish
Pages (from-to)92-101
Number of pages10
JournalDNA Repair
Volume56
DOIs
Publication statusPublished - 1 Aug 2017
Externally publishedYes

Keywords

  • BRCA1/BARD1
  • BRE1
  • DNA damage response
  • Histone ubiquitination
  • PRC1
  • RNF168

Cite this