Histologic, immunohistochemical, microbiological, molecular biological and ultrastructural characterization of pulmonary tularemia

Paula Navarro, Maria L. Garcia-Moliner, James H. McMahon, Sam R. Telford, Driss Zoukhri, Joseph Alroy

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Tularemia is a rare zoonotic disease caused by Francisella tularensis, a Gram-negative bacteria. The clinical manifestations of pulmonary tularemia resemble those of other airways infections. Recently, a case of pulmonary tularemia was diagnosed at Tufts Medical Center. The purpose of the current report is to document the utility of applying several diagnostic tools, including immunohistochemistry, electron microscopy, microbiology and molecular biology in confirming the diagnosis of pulmonary tularemia, particularly in convalescing cases (up to 3 weeks postpresentation) and after antibiotic therapy. Our study demonstrates the usefulness of microbiological studies followed by morphological evaluation and the limitation of the molecular biology analysis of posttherapy samples. © 2010 Elsevier GmbH.

Original languageEnglish
Pages (from-to)63-66
Number of pages4
JournalPathology Research and Practice
Volume207
Issue number1
DOIs
Publication statusPublished - 15 Jan 2011
Externally publishedYes

Keywords

  • Microbiology
  • Molecular biology
  • Morphology
  • Tularemia

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