Histologic chorioamnionitis in preterm infants

Correlation with brain magnetic resonance imaging at term equivalent age

Claire Granger, Alicia J. Spittle, Jennifer Walsh, Jan Pyman, Peter J. Anderson, Deanne K. Thompson, Katherine J. Lee, Lee Coleman, Charuta Dagia, Lex W. Doyle, Jeanie Cheong

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Abstract

Background: To explore the associations between histologic chorioamnionitis with brain injury, maturation and size on magnetic resonance imaging (MRI) of preterm infants at term equivalent age. Methods: Preterm infants (23-36 weeks' gestational age) were recruited into two longitudinal cohort studies. Presence or absence of chorioamnionitis was obtained from placental histology and clinical data were recorded. MRI at term-equivalent age was assessed for brain injury (intraventricular haemorrhage, cysts, signal abnormalities), maturation (degree of myelination, gyral maturation) and size of cerebral structures (metrics and brain segmentation). Histologic chorioamnionitis was assessed as a predictor of MRI variables using linear and logistic regression, with adjustment for confounding perinatal variables. Results: Two hundred and twelve infants were included in this study, 47 (22%) of whom had histologic chorioamnionitis. Histologic chorioamnionitis was associated with higher odds of intraventricular haemorrhage (odds ratio [OR] (95% confidence interval [CI]) = 7.4 (2.4, 23.1)), less mature gyral maturation (OR (95% CI) = 2.0 (1.0, 3.8)) and larger brain volume (mean difference in cubic centimeter (95% CI) of 14.1 (1.9, 26.2)); but all relationships disappeared following adjustment for perinatal variables. Conclusion: Histologic chorioamnionitis was not independently associated with IVH, less mature gyral maturation or brain volume at term-equivalent age in preterm infants.

Original languageEnglish
Article number63
Number of pages7
JournalBMC Pediatrics
Volume18
Issue number1
DOIs
Publication statusPublished - 15 Feb 2018

Keywords

  • Brain volumes
  • Chorioamnionitis
  • Intraventricular haemorrhage
  • Magnetic resonance imaging
  • Preterm

Cite this

Granger, Claire ; Spittle, Alicia J. ; Walsh, Jennifer ; Pyman, Jan ; Anderson, Peter J. ; Thompson, Deanne K. ; Lee, Katherine J. ; Coleman, Lee ; Dagia, Charuta ; Doyle, Lex W. ; Cheong, Jeanie. / Histologic chorioamnionitis in preterm infants : Correlation with brain magnetic resonance imaging at term equivalent age. In: BMC Pediatrics. 2018 ; Vol. 18, No. 1.
@article{07430c754fde4da3867ed8524e317ece,
title = "Histologic chorioamnionitis in preterm infants: Correlation with brain magnetic resonance imaging at term equivalent age",
abstract = "Background: To explore the associations between histologic chorioamnionitis with brain injury, maturation and size on magnetic resonance imaging (MRI) of preterm infants at term equivalent age. Methods: Preterm infants (23-36 weeks' gestational age) were recruited into two longitudinal cohort studies. Presence or absence of chorioamnionitis was obtained from placental histology and clinical data were recorded. MRI at term-equivalent age was assessed for brain injury (intraventricular haemorrhage, cysts, signal abnormalities), maturation (degree of myelination, gyral maturation) and size of cerebral structures (metrics and brain segmentation). Histologic chorioamnionitis was assessed as a predictor of MRI variables using linear and logistic regression, with adjustment for confounding perinatal variables. Results: Two hundred and twelve infants were included in this study, 47 (22{\%}) of whom had histologic chorioamnionitis. Histologic chorioamnionitis was associated with higher odds of intraventricular haemorrhage (odds ratio [OR] (95{\%} confidence interval [CI]) = 7.4 (2.4, 23.1)), less mature gyral maturation (OR (95{\%} CI) = 2.0 (1.0, 3.8)) and larger brain volume (mean difference in cubic centimeter (95{\%} CI) of 14.1 (1.9, 26.2)); but all relationships disappeared following adjustment for perinatal variables. Conclusion: Histologic chorioamnionitis was not independently associated with IVH, less mature gyral maturation or brain volume at term-equivalent age in preterm infants.",
keywords = "Brain volumes, Chorioamnionitis, Intraventricular haemorrhage, Magnetic resonance imaging, Preterm",
author = "Claire Granger and Spittle, {Alicia J.} and Jennifer Walsh and Jan Pyman and Anderson, {Peter J.} and Thompson, {Deanne K.} and Lee, {Katherine J.} and Lee Coleman and Charuta Dagia and Doyle, {Lex W.} and Jeanie Cheong",
year = "2018",
month = "2",
day = "15",
doi = "10.1186/s12887-018-1001-6",
language = "English",
volume = "18",
journal = "BMC Pediatrics",
issn = "1471-2431",
publisher = "Springer-Verlag London Ltd.",
number = "1",

}

Granger, C, Spittle, AJ, Walsh, J, Pyman, J, Anderson, PJ, Thompson, DK, Lee, KJ, Coleman, L, Dagia, C, Doyle, LW & Cheong, J 2018, 'Histologic chorioamnionitis in preterm infants: Correlation with brain magnetic resonance imaging at term equivalent age', BMC Pediatrics, vol. 18, no. 1, 63. https://doi.org/10.1186/s12887-018-1001-6

Histologic chorioamnionitis in preterm infants : Correlation with brain magnetic resonance imaging at term equivalent age. / Granger, Claire; Spittle, Alicia J.; Walsh, Jennifer; Pyman, Jan; Anderson, Peter J.; Thompson, Deanne K.; Lee, Katherine J.; Coleman, Lee; Dagia, Charuta; Doyle, Lex W.; Cheong, Jeanie.

In: BMC Pediatrics, Vol. 18, No. 1, 63, 15.02.2018.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Histologic chorioamnionitis in preterm infants

T2 - Correlation with brain magnetic resonance imaging at term equivalent age

AU - Granger, Claire

AU - Spittle, Alicia J.

AU - Walsh, Jennifer

AU - Pyman, Jan

AU - Anderson, Peter J.

AU - Thompson, Deanne K.

AU - Lee, Katherine J.

AU - Coleman, Lee

AU - Dagia, Charuta

AU - Doyle, Lex W.

AU - Cheong, Jeanie

PY - 2018/2/15

Y1 - 2018/2/15

N2 - Background: To explore the associations between histologic chorioamnionitis with brain injury, maturation and size on magnetic resonance imaging (MRI) of preterm infants at term equivalent age. Methods: Preterm infants (23-36 weeks' gestational age) were recruited into two longitudinal cohort studies. Presence or absence of chorioamnionitis was obtained from placental histology and clinical data were recorded. MRI at term-equivalent age was assessed for brain injury (intraventricular haemorrhage, cysts, signal abnormalities), maturation (degree of myelination, gyral maturation) and size of cerebral structures (metrics and brain segmentation). Histologic chorioamnionitis was assessed as a predictor of MRI variables using linear and logistic regression, with adjustment for confounding perinatal variables. Results: Two hundred and twelve infants were included in this study, 47 (22%) of whom had histologic chorioamnionitis. Histologic chorioamnionitis was associated with higher odds of intraventricular haemorrhage (odds ratio [OR] (95% confidence interval [CI]) = 7.4 (2.4, 23.1)), less mature gyral maturation (OR (95% CI) = 2.0 (1.0, 3.8)) and larger brain volume (mean difference in cubic centimeter (95% CI) of 14.1 (1.9, 26.2)); but all relationships disappeared following adjustment for perinatal variables. Conclusion: Histologic chorioamnionitis was not independently associated with IVH, less mature gyral maturation or brain volume at term-equivalent age in preterm infants.

AB - Background: To explore the associations between histologic chorioamnionitis with brain injury, maturation and size on magnetic resonance imaging (MRI) of preterm infants at term equivalent age. Methods: Preterm infants (23-36 weeks' gestational age) were recruited into two longitudinal cohort studies. Presence or absence of chorioamnionitis was obtained from placental histology and clinical data were recorded. MRI at term-equivalent age was assessed for brain injury (intraventricular haemorrhage, cysts, signal abnormalities), maturation (degree of myelination, gyral maturation) and size of cerebral structures (metrics and brain segmentation). Histologic chorioamnionitis was assessed as a predictor of MRI variables using linear and logistic regression, with adjustment for confounding perinatal variables. Results: Two hundred and twelve infants were included in this study, 47 (22%) of whom had histologic chorioamnionitis. Histologic chorioamnionitis was associated with higher odds of intraventricular haemorrhage (odds ratio [OR] (95% confidence interval [CI]) = 7.4 (2.4, 23.1)), less mature gyral maturation (OR (95% CI) = 2.0 (1.0, 3.8)) and larger brain volume (mean difference in cubic centimeter (95% CI) of 14.1 (1.9, 26.2)); but all relationships disappeared following adjustment for perinatal variables. Conclusion: Histologic chorioamnionitis was not independently associated with IVH, less mature gyral maturation or brain volume at term-equivalent age in preterm infants.

KW - Brain volumes

KW - Chorioamnionitis

KW - Intraventricular haemorrhage

KW - Magnetic resonance imaging

KW - Preterm

UR - http://www.scopus.com/inward/record.url?scp=85042092909&partnerID=8YFLogxK

U2 - 10.1186/s12887-018-1001-6

DO - 10.1186/s12887-018-1001-6

M3 - Article

VL - 18

JO - BMC Pediatrics

JF - BMC Pediatrics

SN - 1471-2431

IS - 1

M1 - 63

ER -