Histocompatibility linked immune responsiveness and restrictions imposed on sensitized lymphocytes*

J. F A P Miller, M. A. Vadas, Alison Whitelaw, Jennifer Gamble, C. Bernard

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Delayed-type hypersensitivity (DTH) transfer to GAT was restricted by the I-A region of the major histocompatibility complex (MHC). Sensitized cells from F1 hybrid mice between responder and nonresponder strains transferred DTH to syngeneic F1 mice and to naive parental strain recipients of the responder but not of the nonresponder haplotypes. These results are interpreted to favor the postulate that the MHC-linked Ir genes exert their effects by coding for components which allow interactions between particular I region gene products and the region to form stable structures immunogenic for DTH T cells.

Original languageEnglish
Pages (from-to)1623-1628
Number of pages6
JournalJournal of Experimental Medicine
Issue number6
Publication statusPublished - 1 Jun 1977
Externally publishedYes

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