Histocompatibility linked immune responsiveness and restrictions imposed on sensitized lymphocytes*

J. F A P Miller; M. A. Vadas; Alison Whitelaw; Jennifer Gamble; C. Bernard

doi:10.1084/jem.145.6.1623

Histocompatibility linked immune responsiveness and restrictions imposed on sensitized lymphocytes*

J. F A P Miller, M. A. Vadas, Alison Whitelaw, Jennifer Gamble, C. Bernard

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Delayed-type hypersensitivity (DTH) transfer to GAT was restricted by the I-A region of the major histocompatibility complex (MHC). Sensitized cells from F₁ hybrid mice between responder and nonresponder strains transferred DTH to syngeneic F₁ mice and to naive parental strain recipients of the responder but not of the nonresponder haplotypes. These results are interpreted to favor the postulate that the MHC-linked Ir genes exert their effects by coding for components which allow interactions between particular I region gene products and the region to form stable structures immunogenic for DTH T cells.

Original language	English
Pages (from-to)	1623-1628
Number of pages	6
Journal	Journal of Experimental Medicine
Volume	145
Issue number	6
DOIs	https://doi.org/10.1084/jem.145.6.1623
Publication status	Published - 1 Jun 1977
Externally published	Yes

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10.1084/jem.145.6.1623

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year = "1977",

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AU - Vadas, M. A.

AU - Whitelaw, Alison

AU - Gamble, Jennifer

AU - Bernard, C.

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JO - Journal of Experimental Medicine

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Histocompatibility linked immune responsiveness and restrictions imposed on sensitized lymphocytes*

Abstract

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