Hippocampal Volume and Amyloid PET Status Three Years after Ischemic Stroke: A Pilot Study

Amy Brodtmann; Mohamed Salah Khlif; Laura J. Bird; Toby Cumming; Emilio Werden

doi:10.3233/JAD-201525

Hippocampal Volume and Amyloid PET Status Three Years after Ischemic Stroke: A Pilot Study

Amy Brodtmann, Mohamed Salah Khlif, Laura J. Bird, Toby Cumming, Emilio Werden

Eastern Health Clinical School

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

Hippocampal atrophy is seen in many neurodegenerative disorders and may be a cardinal feature of vascular neurodegeneration. We examined hippocampal volume (HV) in a group of ischemic stroke survivors with amyloid 18F-NAV4694 PET imaging three years after stroke. We compared HV between the amyloid-positive (n=4) and amyloid-negative (n=29) groups, and associations with co-morbidities using Charlson Comorbidity Indices and multi-way ANOVA. Amyloid status was not associated with verbal or visual delayed free recall memory indices or cognitive impairment. We found no association between amyloid status and HV in this group of ischemic stroke survivors.

Original language	English
Pages (from-to)	527-532
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	80
Issue number	2
DOIs	https://doi.org/10.3233/JAD-201525
Publication status	Published - 2021

Keywords

F-NAV4694
Amyloid imaging
atrophy
hippocampal volume
ischemic stroke
PET

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10.3233/JAD-201525

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title = "Hippocampal Volume and Amyloid PET Status Three Years after Ischemic Stroke: A Pilot Study",

abstract = "Hippocampal atrophy is seen in many neurodegenerative disorders and may be a cardinal feature of vascular neurodegeneration. We examined hippocampal volume (HV) in a group of ischemic stroke survivors with amyloid 18F-NAV4694 PET imaging three years after stroke. We compared HV between the amyloid-positive (n=4) and amyloid-negative (n=29) groups, and associations with co-morbidities using Charlson Comorbidity Indices and multi-way ANOVA. Amyloid status was not associated with verbal or visual delayed free recall memory indices or cognitive impairment. We found no association between amyloid status and HV in this group of ischemic stroke survivors.",

keywords = "F-NAV4694, Amyloid imaging, atrophy, hippocampal volume, ischemic stroke, PET",

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note = "Funding Information: This work was supported by NHMRC grants GNT1020526 and GNT1094974 (AB) and Heart Foundation Future Leader Fellowship (AB, 100784). Publisher Copyright: {\textcopyright} 2021-IOS Press. All rights reserved.",

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doi = "10.3233/JAD-201525",

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volume = "80",

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journal = "Journal of Alzheimer's Disease",

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T1 - Hippocampal Volume and Amyloid PET Status Three Years after Ischemic Stroke

T2 - A Pilot Study

AU - Brodtmann, Amy

AU - Khlif, Mohamed Salah

AU - Bird, Laura J.

AU - Cumming, Toby

AU - Werden, Emilio

N1 - Funding Information: This work was supported by NHMRC grants GNT1020526 and GNT1094974 (AB) and Heart Foundation Future Leader Fellowship (AB, 100784). Publisher Copyright: © 2021-IOS Press. All rights reserved.

PY - 2021

Y1 - 2021

N2 - Hippocampal atrophy is seen in many neurodegenerative disorders and may be a cardinal feature of vascular neurodegeneration. We examined hippocampal volume (HV) in a group of ischemic stroke survivors with amyloid 18F-NAV4694 PET imaging three years after stroke. We compared HV between the amyloid-positive (n=4) and amyloid-negative (n=29) groups, and associations with co-morbidities using Charlson Comorbidity Indices and multi-way ANOVA. Amyloid status was not associated with verbal or visual delayed free recall memory indices or cognitive impairment. We found no association between amyloid status and HV in this group of ischemic stroke survivors.

AB - Hippocampal atrophy is seen in many neurodegenerative disorders and may be a cardinal feature of vascular neurodegeneration. We examined hippocampal volume (HV) in a group of ischemic stroke survivors with amyloid 18F-NAV4694 PET imaging three years after stroke. We compared HV between the amyloid-positive (n=4) and amyloid-negative (n=29) groups, and associations with co-morbidities using Charlson Comorbidity Indices and multi-way ANOVA. Amyloid status was not associated with verbal or visual delayed free recall memory indices or cognitive impairment. We found no association between amyloid status and HV in this group of ischemic stroke survivors.

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KW - hippocampal volume

KW - ischemic stroke

KW - PET

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Hippocampal Volume and Amyloid PET Status Three Years after Ischemic Stroke: A Pilot Study

Abstract

Keywords

UN SDGs

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