Hippocampal shape variations at term equivalent age in very preterm infants compared with term controls: perinatal predictors and functional significance at age 7

Deanne K Thompson, Christopher Adamson, Gehan Roberts, Nathan Faggian, Stephen J Wood, Simon K Warfield, Lex Doyle, Peter J. Anderson, Gary Francis Egan, Terrie Inder

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39 Citations (Scopus)

Abstract

The hippocampus undergoes rapid growth and development in the perinatal months. Infants born very preterm (VPT) are vulnerable to hippocampal alterations, and can provide a model of disturbed early hippocampal development. Hippocampal shape alterations have previously been associated with memory impairment, but have never been investigated in infants. The aims of this study were to determine hippocampal shape differences between 184 VPT infants (<30 weeks gestation or <1250 g at birth) and 32 full-term infants, effects of perinatal factors, and associations between infant hippocampal shape and volume, and 7 year verbal and visual memory (California Verbal Learning Test - Children s Version and Dot Locations).
Original languageEnglish
Pages (from-to)278 - 287
Number of pages10
JournalNeuroImage
Volume70
DOIs
Publication statusPublished - 2013

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