Hippocampal shape variations at term equivalent age in very preterm infants compared with term controls: perinatal predictors and functional significance at age 7

Deanne K Thompson; Christopher Adamson; Gehan Roberts; Nathan Faggian; Stephen J Wood; Simon K Warfield; Lex Doyle; Peter J. Anderson; Gary Francis Egan; Terrie Inder

doi:10.1016/j.neuroimage.2012.12.053

Hippocampal shape variations at term equivalent age in very preterm infants compared with term controls: perinatal predictors and functional significance at age 7

Deanne K Thompson, Christopher Adamson, Gehan Roberts, Nathan Faggian, Stephen J Wood, Simon K Warfield, Lex Doyle, Peter J. Anderson, Gary Francis Egan, Terrie Inder

School of Psychological Sciences

Research output: Contribution to journal › Article › Research › peer-review

58 Citations (Scopus)

Abstract

The hippocampus undergoes rapid growth and development in the perinatal months. Infants born very preterm (VPT) are vulnerable to hippocampal alterations, and can provide a model of disturbed early hippocampal development. Hippocampal shape alterations have previously been associated with memory impairment, but have never been investigated in infants. The aims of this study were to determine hippocampal shape differences between 184 VPT infants (<30 weeks gestation or <1250 g at birth) and 32 full-term infants, effects of perinatal factors, and associations between infant hippocampal shape and volume, and 7 year verbal and visual memory (California Verbal Learning Test - Children s Version and Dot Locations).

Original language	English
Pages (from-to)	278 - 287
Number of pages	10
Journal	NeuroImage
Volume	70
DOIs	https://doi.org/10.1016/j.neuroimage.2012.12.053
Publication status	Published - 2013

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Thompson, D. K., Adamson, C., Roberts, G., Faggian, N., Wood, S. J., Warfield, S. K., Doyle, L., Anderson, P. J., Egan, G. F., & Inder, T. (2013). Hippocampal shape variations at term equivalent age in very preterm infants compared with term controls: perinatal predictors and functional significance at age 7. NeuroImage, 70, 278 - 287. https://doi.org/10.1016/j.neuroimage.2012.12.053

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title = "Hippocampal shape variations at term equivalent age in very preterm infants compared with term controls: perinatal predictors and functional significance at age 7",

abstract = "The hippocampus undergoes rapid growth and development in the perinatal months. Infants born very preterm (VPT) are vulnerable to hippocampal alterations, and can provide a model of disturbed early hippocampal development. Hippocampal shape alterations have previously been associated with memory impairment, but have never been investigated in infants. The aims of this study were to determine hippocampal shape differences between 184 VPT infants (<30 weeks gestation or <1250 g at birth) and 32 full-term infants, effects of perinatal factors, and associations between infant hippocampal shape and volume, and 7 year verbal and visual memory (California Verbal Learning Test - Children s Version and Dot Locations).",

author = "Thompson, {Deanne K} and Christopher Adamson and Gehan Roberts and Nathan Faggian and Wood, {Stephen J} and Warfield, {Simon K} and Lex Doyle and Anderson, {Peter J.} and Egan, {Gary Francis} and Terrie Inder",

year = "2013",

doi = "10.1016/j.neuroimage.2012.12.053",

language = "English",

volume = "70",

pages = "278 -- 287",

journal = "NeuroImage",

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publisher = "Elsevier BV",

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Thompson, DK, Adamson, C, Roberts, G, Faggian, N, Wood, SJ, Warfield, SK, Doyle, L, Anderson, PJ, Egan, GF & Inder, T 2013, 'Hippocampal shape variations at term equivalent age in very preterm infants compared with term controls: perinatal predictors and functional significance at age 7', NeuroImage, vol. 70, pp. 278 - 287. https://doi.org/10.1016/j.neuroimage.2012.12.053

TY - JOUR

T1 - Hippocampal shape variations at term equivalent age in very preterm infants compared with term controls: perinatal predictors and functional significance at age 7

AU - Thompson, Deanne K

AU - Adamson, Christopher

AU - Roberts, Gehan

AU - Faggian, Nathan

AU - Wood, Stephen J

AU - Warfield, Simon K

AU - Doyle, Lex

AU - Anderson, Peter J.

AU - Egan, Gary Francis

AU - Inder, Terrie

PY - 2013

Y1 - 2013

N2 - The hippocampus undergoes rapid growth and development in the perinatal months. Infants born very preterm (VPT) are vulnerable to hippocampal alterations, and can provide a model of disturbed early hippocampal development. Hippocampal shape alterations have previously been associated with memory impairment, but have never been investigated in infants. The aims of this study were to determine hippocampal shape differences between 184 VPT infants (<30 weeks gestation or <1250 g at birth) and 32 full-term infants, effects of perinatal factors, and associations between infant hippocampal shape and volume, and 7 year verbal and visual memory (California Verbal Learning Test - Children s Version and Dot Locations).

AB - The hippocampus undergoes rapid growth and development in the perinatal months. Infants born very preterm (VPT) are vulnerable to hippocampal alterations, and can provide a model of disturbed early hippocampal development. Hippocampal shape alterations have previously been associated with memory impairment, but have never been investigated in infants. The aims of this study were to determine hippocampal shape differences between 184 VPT infants (<30 weeks gestation or <1250 g at birth) and 32 full-term infants, effects of perinatal factors, and associations between infant hippocampal shape and volume, and 7 year verbal and visual memory (California Verbal Learning Test - Children s Version and Dot Locations).

UR - http://www.sciencedirect.com/science/article/pii/S1053811912012396

U2 - 10.1016/j.neuroimage.2012.12.053

DO - 10.1016/j.neuroimage.2012.12.053

M3 - Article

SN - 1053-8119

VL - 70

SP - 278

EP - 287

JO - NeuroImage

JF - NeuroImage

ER -

Hippocampal shape variations at term equivalent age in very preterm infants compared with term controls: perinatal predictors and functional significance at age 7

Abstract

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