Highways for protein delivery to the mitochondria

Trevor Lithgow; José M. Cuezva; Pamela A. Silver

doi:10.1016/S0968-0004(97)01007-4

Highways for protein delivery to the mitochondria

Trevor Lithgow, José M. Cuezva, Pamela A. Silver

Research output: Contribution to journal › Short Survey › Research › peer-review

51 Citations (Scopus)

Abstract

Messenger RNA (mRNA) localisation is one of the prime mechanisms to ensure protein localisation in the cytoplasm of polarised embryonic cells, and has been well-studied in the development of Xenopus and Drosophila embryos. But what of other cells? Here, we discuss whether the directed transport of mRNA out of the nucleus, following cytoplasmic highways to a specified organelle in the cytoplasm, might also contribute to the exquisite fidelity of protein targeting observed in all eukaryotic cells.

Original language	English
Pages (from-to)	110-113
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/S0968-0004(97)01007-4
Publication status	Published - 1 Apr 1997
Externally published	Yes

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10.1016/S0968-0004(97)01007-4

Link to publication in Scopus

Cite this

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title = "Highways for protein delivery to the mitochondria",

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AU - Cuezva, José M.

AU - Silver, Pamela A.

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N2 - Messenger RNA (mRNA) localisation is one of the prime mechanisms to ensure protein localisation in the cytoplasm of polarised embryonic cells, and has been well-studied in the development of Xenopus and Drosophila embryos. But what of other cells? Here, we discuss whether the directed transport of mRNA out of the nucleus, following cytoplasmic highways to a specified organelle in the cytoplasm, might also contribute to the exquisite fidelity of protein targeting observed in all eukaryotic cells.

AB - Messenger RNA (mRNA) localisation is one of the prime mechanisms to ensure protein localisation in the cytoplasm of polarised embryonic cells, and has been well-studied in the development of Xenopus and Drosophila embryos. But what of other cells? Here, we discuss whether the directed transport of mRNA out of the nucleus, following cytoplasmic highways to a specified organelle in the cytoplasm, might also contribute to the exquisite fidelity of protein targeting observed in all eukaryotic cells.

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DO - 10.1016/S0968-0004(97)01007-4

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