Highly branched and hyperbranched glycopolymers via reversible addition-fragmentation chain transfer polymerization and click chemistry

Mona Semsarilar, Vincent Ladmiral, Sébastien Perrier

Research output: Contribution to journalArticleResearchpeer-review

122 Citations (Scopus)

Abstract

We report a new strategy to synthesize densely functionalized highly and hyperbranched glycopolymers. Our methodology combines living radical polymerization and click chemistry. Hyperbranched "clickable" scaffolds synthesized via RAFT polymerization are functionalized with carbohydrate groups using an array of "click" chemistry reactions, namely Cu(I)-catalyzed Huisgen 1,3-cycloaddition of azides and alkynes (CuAAC), thiol-ene addition, and thiol-yne addition. This simple and flexible method yields glycopolymers of unique structures, which are potential candidates for biomedical applications.

Original languageEnglish
Pages (from-to)1438-1443
Number of pages6
JournalMacromolecules
Volume43
Issue number3
DOIs
Publication statusPublished - 9 Feb 2010
Externally publishedYes

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