Higher levels of collagen and facilitated healing protect against ventricular rupture following myocardial infarction

Lu Fang, Xiao-Ming Gao, Chrishan Samuel, Y Su, Yean Leng Lim, Anthony Dart, Xiao-Jun Du

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13 Citations (Scopus)

Abstract

The mechanism of cardiac rupture after MI (myocardial infarction) is not fully understood. Rupture has not been reported in most laboratory species, including the rat, but does occur in mice. We have reported previously that beta2-TG mice (transgenic mice with cardiac-restricted overexpression of beta2-adrenergic receptors) had a lower incidence of rupture compared with NTG (non-transgenic) littermates. We hypothesized that the difference in the incidence of rupture between rodents and specific mouse strains is due to the difference in collagen content following MI. In the present study, we compared the difference in matrix remodelling post-MI between beta2-TG and NTG mice and between mice and rats. MI was induced by ligation of the left main coronary artery. Following MI, tensile strength, insoluble and soluble collagen content and gelatinase expression were determined in the infarcted and non-infarcted myocardium. Better preserved tensile strength measured as TTR [tension-to-rupture; 88+/-14 and 58+/-3 of the respective sham group values for beta2-TG compared with NTG mice (P
Original languageEnglish
Pages (from-to)99 - 106
Number of pages8
JournalClinical Science
Volume115
Issue number3
DOIs
Publication statusPublished - 2008
Externally publishedYes

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