High throughput techniques for the investigation of cell-material interactions

Lauren R. Clements, Helmut Thissen, Nicolas H. Voelcker

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review


The evaluation and control of the cellular response to substrate materials is important for a wide range of regenerative medicine applications including implants, biomaterial devices and biosensors. Gradient surfaces provide a simple and fast method for determining optimal surface conditions for cellular responses such as attachment and growth. This chapter presents an overview of high-throughput techniques available for the optimisation of cell material interactions with particular emphasis on surface topographical and chemical gradients. The gradient approaches presented throughout this chapter are expected to become useful tools for researchers that are aiming to optimise advanced materials for a variety of biomedical applications.
Original languageEnglish
Title of host publicationBiointerfaces
Subtitle of host publicationWhere Material Meets Biology
EditorsDietmar Hutmacher, Wojciech Chrzanowski
Place of PublicationCambridge UK
PublisherThe Royal Society of Chemistry
Number of pages53
ISBN (Electronic)9781782628453
ISBN (Print)9781849738767
Publication statusPublished - 2015
Externally publishedYes

Publication series

NameRSC Smart Materials
PublisherThe Royal Society of Chemistry
ISSN (Print)2046-0066

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