Abstract
The preparation, characterisation and assessment of drug delivery vehicles is typically a slow and complex
process. Here we present a nanostructured nanoparticle system that can be prepared and characterised
in a high-throughput fashion. In particular we use phytantriol and MyverolTM to prepare inverse bicontinuous
cubic and inverse hexagonal liquid crystalline nanoparticles loaded with 10 commonly used
therapeutic agents at increasing concentration. The dispersions are prepared using automated apparatus
to create different concentrations and phases using novel protocols. We are able to characterise each
stabilised nanoparticle dispersion using a range of methodologies including small angle X-ray scattering,
particle sizing and drug partitioning. With this informationweare able to assess which drug delivery vehicle
is preferred for each drug and at which concentration the drug should be loaded to ensure maximum
payload and to retain particle integrity.
Original language | English |
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Pages (from-to) | 290 - 297 |
Number of pages | 8 |
Journal | International Journal of Pharmaceutics |
Volume | 395 |
Issue number | 1-2 |
DOIs | |
Publication status | Published - 2010 |