High-throughput cell manipulation using ultrasound fields

Deok Ho Kim, Albrecht Haake, Yu Sun, Adrian P. Neild, Jong Eun Ihm, Jürg Dual, Jeffrey A. Hubbell, Byeong Kwon Ju, Bradley J. Nelson

Research output: Chapter in Book/Report/Conference proceedingConference PaperOther

11 Citations (Scopus)

Abstract

This paper presents a novel method for high-throughput cell manipulation that is capable of trapping and transporting biological cells in liquid using acoustic forces in an ultrasound field. We applied this technique for concentrating several cell types such as HeLa cells and human mesencymal stem cells. More than 90% of the cells were successfully concentrated into desired patterns. We also investigated cell viability in ultrasound fields and found little adverse effect. This work demonstrates that ultrasonic cell manipulation is suitable for being integrated into lab-on-a-chip systems for trapping and transporting large numbers of cells rapidly and is promising in cell fractioning.

Original languageEnglish
Title of host publication26th International Conference of the IEEE Engineering in Medicine and Biology Society 2004
Subtitle of host publicationConference Proceedings
Pages2571-2574
Number of pages4
Volume26 IV
Publication statusPublished - 2004
Externally publishedYes
EventInternational Conference of the IEEE Engineering in Medicine and Biology Society 2004 - San Francisco, United States of America
Duration: 1 Sept 20045 Sept 2004
Conference number: 26th
https://ieeexplore.ieee.org/xpl/conhome/9639/proceeding?isnumber=30462 (Proceedings)

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN (Print)0589-1019

Conference

ConferenceInternational Conference of the IEEE Engineering in Medicine and Biology Society 2004
Abbreviated titleEMBC 2004
Country/TerritoryUnited States of America
CitySan Francisco
Period1/09/045/09/04
Internet address

Keywords

  • Cell manipulation
  • Cell sorting
  • High-throughput
  • Ultrasound field
  • Viability

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