High-throughput cell manipulation using ultrasound fields

Deok Ho Kim; Albrecht Haake; Yu Sun; Adrian P. Neild; Jong Eun Ihm; Jürg Dual; Jeffrey A. Hubbell; Byeong Kwon Ju; Bradley J. Nelson

High-throughput cell manipulation using ultrasound fields

Deok Ho Kim, Albrecht Haake, Yu Sun, Adrian P. Neild, Jong Eun Ihm, Jürg Dual, Jeffrey A. Hubbell, Byeong Kwon Ju, Bradley J. Nelson

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

17 Citations (Scopus)

Abstract

This paper presents a novel method for high-throughput cell manipulation that is capable of trapping and transporting biological cells in liquid using acoustic forces in an ultrasound field. We applied this technique for concentrating several cell types such as HeLa cells and human mesencymal stem cells. More than 90% of the cells were successfully concentrated into desired patterns. We also investigated cell viability in ultrasound fields and found little adverse effect. This work demonstrates that ultrasonic cell manipulation is suitable for being integrated into lab-on-a-chip systems for trapping and transporting large numbers of cells rapidly and is promising in cell fractioning.

Original language	English
Title of host publication	26th International Conference of the IEEE Engineering in Medicine and Biology Society 2004
Subtitle of host publication	Conference Proceedings
Pages	2571-2574
Number of pages	4
Volume	26 IV
Publication status	Published - 2004
Externally published	Yes
Event	International Conference of the IEEE Engineering in Medicine and Biology Society 2004 - San Francisco, United States of America Duration: 1 Sept 2004 → 5 Sept 2004 Conference number: 26th https://ieeexplore.ieee.org/xpl/conhome/9639/proceeding?isnumber=30462 (Proceedings)

Publication series

Name	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
ISSN (Print)	0589-1019

Conference

Conference	International Conference of the IEEE Engineering in Medicine and Biology Society 2004
Abbreviated title	EMBC 2004
Country/Territory	United States of America
City	San Francisco
Period	1/09/04 → 5/09/04
Internet address	https://ieeexplore.ieee.org/xpl/conhome/9639/proceeding?isnumber=30462 (Proceedings)

Keywords

Cell manipulation
Cell sorting
High-throughput
Ultrasound field
Viability

Cite this

Kim, D. H., Haake, A., Sun, Y., Neild, A. P., Ihm, J. E., Dual, J., Hubbell, J. A., Ju, B. K., & Nelson, B. J. (2004). High-throughput cell manipulation using ultrasound fields. In 26th International Conference of the IEEE Engineering in Medicine and Biology Society 2004: Conference Proceedings (Vol. 26 IV, pp. 2571-2574). (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

@inproceedings{89893643932548049dc63699297650fe,

title = "High-throughput cell manipulation using ultrasound fields",

abstract = "This paper presents a novel method for high-throughput cell manipulation that is capable of trapping and transporting biological cells in liquid using acoustic forces in an ultrasound field. We applied this technique for concentrating several cell types such as HeLa cells and human mesencymal stem cells. More than 90% of the cells were successfully concentrated into desired patterns. We also investigated cell viability in ultrasound fields and found little adverse effect. This work demonstrates that ultrasonic cell manipulation is suitable for being integrated into lab-on-a-chip systems for trapping and transporting large numbers of cells rapidly and is promising in cell fractioning.",

keywords = "Cell manipulation, Cell sorting, High-throughput, Ultrasound field, Viability",

author = "Kim, {Deok Ho} and Albrecht Haake and Yu Sun and Neild, {Adrian P.} and Ihm, {Jong Eun} and J{\"u}rg Dual and Hubbell, {Jeffrey A.} and Ju, {Byeong Kwon} and Nelson, {Bradley J.}",

year = "2004",

language = "English",

volume = "26 IV",

series = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

pages = "2571--2574",

booktitle = "26th International Conference of the IEEE Engineering in Medicine and Biology Society 2004",

note = "International Conference of the IEEE Engineering in Medicine and Biology Society 2004, EMBC 2004 ; Conference date: 01-09-2004 Through 05-09-2004",

url = "https://ieeexplore.ieee.org/xpl/conhome/9639/proceeding?isnumber=30462",

}

Kim, DH, Haake, A, Sun, Y, Neild, AP, Ihm, JE, Dual, J, Hubbell, JA, Ju, BK & Nelson, BJ 2004, High-throughput cell manipulation using ultrasound fields. in 26th International Conference of the IEEE Engineering in Medicine and Biology Society 2004: Conference Proceedings. vol. 26 IV, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, pp. 2571-2574, International Conference of the IEEE Engineering in Medicine and Biology Society 2004, San Francisco, California, United States of America, 1/09/04.

High-throughput cell manipulation using ultrasound fields. / Kim, Deok Ho; Haake, Albrecht; Sun, Yu et al.
26th International Conference of the IEEE Engineering in Medicine and Biology Society 2004: Conference Proceedings. Vol. 26 IV 2004. p. 2571-2574 (Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other

TY - GEN

T1 - High-throughput cell manipulation using ultrasound fields

AU - Kim, Deok Ho

AU - Haake, Albrecht

AU - Sun, Yu

AU - Neild, Adrian P.

AU - Ihm, Jong Eun

AU - Dual, Jürg

AU - Hubbell, Jeffrey A.

AU - Ju, Byeong Kwon

AU - Nelson, Bradley J.

N1 - Conference code: 26th

PY - 2004

Y1 - 2004

N2 - This paper presents a novel method for high-throughput cell manipulation that is capable of trapping and transporting biological cells in liquid using acoustic forces in an ultrasound field. We applied this technique for concentrating several cell types such as HeLa cells and human mesencymal stem cells. More than 90% of the cells were successfully concentrated into desired patterns. We also investigated cell viability in ultrasound fields and found little adverse effect. This work demonstrates that ultrasonic cell manipulation is suitable for being integrated into lab-on-a-chip systems for trapping and transporting large numbers of cells rapidly and is promising in cell fractioning.

AB - This paper presents a novel method for high-throughput cell manipulation that is capable of trapping and transporting biological cells in liquid using acoustic forces in an ultrasound field. We applied this technique for concentrating several cell types such as HeLa cells and human mesencymal stem cells. More than 90% of the cells were successfully concentrated into desired patterns. We also investigated cell viability in ultrasound fields and found little adverse effect. This work demonstrates that ultrasonic cell manipulation is suitable for being integrated into lab-on-a-chip systems for trapping and transporting large numbers of cells rapidly and is promising in cell fractioning.

KW - Cell manipulation

KW - Cell sorting

KW - High-throughput

KW - Ultrasound field

KW - Viability

UR - http://www.scopus.com/inward/record.url?scp=11144286042&partnerID=8YFLogxK

M3 - Conference Paper

AN - SCOPUS:11144286042

VL - 26 IV

T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

SP - 2571

EP - 2574

BT - 26th International Conference of the IEEE Engineering in Medicine and Biology Society 2004

T2 - International Conference of the IEEE Engineering in Medicine and Biology Society 2004

Y2 - 1 September 2004 through 5 September 2004

ER -

High-throughput cell manipulation using ultrasound fields

Abstract

Publication series

Conference

Keywords

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Cite this