High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor

Ossama El-Kabbani; Connie Darmanin; Mitsuru Oka; Clemens Schulze-Briese; Takashi Tomizaki; Isabelle Hazemann; Andre Mitschler; Alberto D Podjarny

doi:10.1021/jm0497794

High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor

Ossama El-Kabbani, Connie Darmanin, Mitsuru Oka, Clemens Schulze-Briese, Takashi Tomizaki, Isabelle Hazemann, Andre Mitschler, Alberto D Podjarny

Medicinal Chemistry

Research output: Contribution to journal › Article › Research › peer-review

27 Citations (Scopus)

Original language	English
Pages (from-to)	4530 - 4537
Number of pages	8
Journal	Journal of Medicinal Chemistry
Volume	47
Issue number	18
DOIs	https://doi.org/10.1021/jm0497794
Publication status	Published - 2004

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10.1021/jm0497794

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El-Kabbani, O., Darmanin, C., Oka, M., Schulze-Briese, C., Tomizaki, T., Hazemann, I., Mitschler, A., & Podjarny, A. D. (2004). High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor. Journal of Medicinal Chemistry, 47(18), 4530 - 4537. https://doi.org/10.1021/jm0497794

El-Kabbani, Ossama ; Darmanin, Connie ; Oka, Mitsuru ; Schulze-Briese, Clemens ; Tomizaki, Takashi ; Hazemann, Isabelle ; Mitschler, Andre ; Podjarny, Alberto D. / High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor. In: Journal of Medicinal Chemistry. 2004 ; Vol. 47, No. 18. pp. 4530 - 4537.

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title = "High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor",

author = "Ossama El-Kabbani and Connie Darmanin and Mitsuru Oka and Clemens Schulze-Briese and Takashi Tomizaki and Isabelle Hazemann and Andre Mitschler and Podjarny, {Alberto D}",

year = "2004",

doi = "10.1021/jm0497794",

language = "English",

volume = "47",

pages = "4530 -- 4537",

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El-Kabbani, O, Darmanin, C, Oka, M, Schulze-Briese, C, Tomizaki, T, Hazemann, I, Mitschler, A & Podjarny, AD 2004, 'High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor', Journal of Medicinal Chemistry, vol. 47, no. 18, pp. 4530 - 4537. https://doi.org/10.1021/jm0497794

High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor. / El-Kabbani, Ossama; Darmanin, Connie; Oka, Mitsuru; Schulze-Briese, Clemens; Tomizaki, Takashi; Hazemann, Isabelle; Mitschler, Andre; Podjarny, Alberto D.

In: Journal of Medicinal Chemistry, Vol. 47, No. 18, 2004, p. 4530 - 4537.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor

AU - El-Kabbani, Ossama

AU - Darmanin, Connie

AU - Oka, Mitsuru

AU - Schulze-Briese, Clemens

AU - Tomizaki, Takashi

AU - Hazemann, Isabelle

AU - Mitschler, Andre

AU - Podjarny, Alberto D

PY - 2004

Y1 - 2004

U2 - 10.1021/jm0497794

DO - 10.1021/jm0497794

M3 - Article

VL - 47

SP - 4530

EP - 4537

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

SN - 0022-2623

IS - 18

ER -

El-Kabbani O, Darmanin C, Oka M, Schulze-Briese C, Tomizaki T, Hazemann I et al. High-resolution structures of human aldose reductase holoenzyme in complex with stereoisomers of the potent inhibitor Fidarestat: stereospecific interaction between the enzyme and a cyclic imide type inhibitor. Journal of Medicinal Chemistry. 2004;47(18):4530 - 4537. https://doi.org/10.1021/jm0497794