High-potency human immunodeficiency virus vaccination leads to delayed and reduced CD8+ T-cell expansion but improved virus control

Miles P. Davenport, Lei Zhang, Ansuman Bagchi, Arthur Fridman, Tong Ming Fu, William Schleif, John W. Shiver, Ruy M. Ribeiro, Alan S. Perelson

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24 Citations (Scopus)

Abstract

CD8+ T lymphocytes are thought to play an important role in the control of acute and chronic human immunodeficiency virus infections. However, there is a significant delay between infection and the first observed increase in virus-specific CD8+ T-cell numbers. Prior to this time, viral kinetics are not significantly different between controls and vaccinees. Surprisingly, higher initial virus-specific CD8+ T-cell numbers lead to a longer delay prior to initial CD8+ T-cell expansion, and slower CD8+ T-cell increases. Nevertheless, higher initial CDS+ T-cell numbers were associated with reduced peak and chronic viral loads and reduced CD4+ T-cell depletion.

Original languageEnglish
Pages (from-to)10059-10062
Number of pages4
JournalJournal of Virology
Volume79
Issue number15
DOIs
Publication statusPublished - Aug 2005
Externally publishedYes

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