High-order multiblock copolymers via iterative Cu(0)-mediated radical polymerizations (SET-LRP): Toward biological precision

Alexander H Soeriyadi, Cyrille Boyer, Fredrik Nystrom, Per B Zetterlund, Michael Raymond Whittaker

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253 Citations (Scopus)


We report a new approach for the facile synthesis of high-order multiblock copolymers comprising very short blocks. The approach entails sequential addition of different monomers via an iterative single electron transfer - living radical polymerization technique, allowing nearly perfect control of the copolymer microstructure. It is possible to synthesize high-order multiblock copolymers with unprecedented control, i.e., A-B-C-D-E-etc., without any need for purification between iterative 24 h block formation steps. To illustrate this concept, we report the synthesis of model P(MA-b-MA...) homopolymer and P(MA-b-nBuA-b-EA-b-2EHA-b-EA-b-nBuA) copolymer in extremely high yield. Finally, the halide end-group can be modified via click chemistry , including thiol - bromide click chemistry, sodium methanethiosulfonate nucleophilic substitution, and atom transfer radical nitroxide coupling reaction, to yield functional, structurally complex macromolecules.
Original languageEnglish
Pages (from-to)11128 - 11131
Number of pages4
JournalJournal of the American Chemical Society
Issue number29
Publication statusPublished - 2011
Externally publishedYes

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