High-Intensity-Focused-Ultrasound (HIFU) induced homeostasis and tissue ablation

S. Chauhan, M. S. Michel, P. Alken, K. U. Köhrmann, A. Haecker

Research output: Contribution to journalConference articleResearchpeer-review

Abstract

At high intensity levels, ultrasound energy focused into remote tissue targets in human body has shown to produce thermal necrosis in circumscribed regions with sub-millimeter accuracy. The non-invasive modality known as HIFU (High Intensity Focused Ultrasound) has enormous potential for thermal ablation of cancers/tumors of the human body without any adverse effects in the surrounding normal tissue. In this paper, empirical results for parameteric assessment and interdependence of several exposure variables are presented for producing thermal necrosis as well as hemostasis. Multiple HIFU transducers in selective spatial configuration have been deployed using a suitably designed experimental harness, with and without motorized jig scanning. The pre-planning and on-line procedure for treatment and specified instrumentation is described. Custom designed 25mm aperture HIFU probes resonating at 2 MHz focused at 64 and 80 mm are used. Results have been obtained in ex-vivo animal tissue (fat, muscle and kidney) and in vitro biological phantoms for hemostasis.

Original languageEnglish
Pages (from-to)237-244
Number of pages8
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume4954
DOIs
Publication statusPublished - 29 Sep 2003
Externally publishedYes
EventThermal treatment of Tissue:Energy Delivery and Assessment II - San Jose,CA, United States of America
Duration: 26 Jan 200327 Jan 2003

Keywords

  • Focal Ultrasound Surgery
  • Hemostasis
  • Multiple probes
  • Tissue ablation
  • Treatment planning

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