Abstract
At high intensity levels, ultrasound energy focused into remote tissue targets in human body has shown to produce thermal necrosis in circumscribed regions with sub-millimeter accuracy. The non-invasive modality known as HIFU (High Intensity Focused Ultrasound) has enormous potential for thermal ablation of cancers/tumors of the human body without any adverse effects in the surrounding normal tissue. In this paper, empirical results for parameteric assessment and interdependence of several exposure variables are presented for producing thermal necrosis as well as hemostasis. Multiple HIFU transducers in selective spatial configuration have been deployed using a suitably designed experimental harness, with and without motorized jig scanning. The pre-planning and on-line procedure for treatment and specified instrumentation is described. Custom designed 25mm aperture HIFU probes resonating at 2 MHz focused at 64 and 80 mm are used. Results have been obtained in ex-vivo animal tissue (fat, muscle and kidney) and in vitro biological phantoms for hemostasis.
| Original language | English |
|---|---|
| Pages (from-to) | 237-244 |
| Number of pages | 8 |
| Journal | Proceedings of SPIE - The International Society for Optical Engineering |
| Volume | 4954 |
| DOIs | |
| Publication status | Published - 29 Sept 2003 |
| Externally published | Yes |
| Event | Thermal treatment of Tissue:Energy Delivery and Assessment II - San Jose,CA, United States of America Duration: 26 Jan 2003 → 27 Jan 2003 |
Keywords
- Focal Ultrasound Surgery
- Hemostasis
- Multiple probes
- Tissue ablation
- Treatment planning
