High-Intensity Exercise and Mitochondrial Biogenesis: Current Controversies and Future Research Directions

David J. Bishop, Javier Botella, Amanda J. Genders, Matthew J.C. Lee, Nicholas J. Saner, Jujiao Kuang, Xu Yan, Cesare Granata

Research output: Contribution to journalReview ArticleResearchpeer-review

18 Citations (Scopus)


It is well established that different types of exercise can provide a powerful stimulus for mitochondrial biogenesis. However, there are conflicting findings in the literature, and a consensus has not been reached regarding the efficacy of high-intensity exercise to promote mitochondrial biogenesis in humans. The purpose of this review is to examine current controversies in the field and to highlight some important methodological issues that need to be addressed to resolve existing conflicts.

Original languageEnglish
Pages (from-to)56-70
Number of pages15
Issue number1
Publication statusPublished - 1 Jan 2019

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