High-Intensity Exercise and Mitochondrial Biogenesis: Current Controversies and Future Research Directions

David J. Bishop; Javier Botella; Amanda J. Genders; Matthew J.C. Lee; Nicholas J. Saner; Jujiao Kuang; Xu Yan; Cesare Granata

doi:10.1152/physiol.00038.2018

High-Intensity Exercise and Mitochondrial Biogenesis: Current Controversies and Future Research Directions

David J. Bishop, Javier Botella, Amanda J. Genders, Matthew J.C. Lee, Nicholas J. Saner, Jujiao Kuang, Xu Yan, Cesare Granata

Diabetes

Research output: Contribution to journal › Review Article › Research › peer-review

18 Citations (Scopus)

Abstract

It is well established that different types of exercise can provide a powerful stimulus for mitochondrial biogenesis. However, there are conflicting findings in the literature, and a consensus has not been reached regarding the efficacy of high-intensity exercise to promote mitochondrial biogenesis in humans. The purpose of this review is to examine current controversies in the field and to highlight some important methodological issues that need to be addressed to resolve existing conflicts.

Original language	English
Pages (from-to)	56-70
Number of pages	15
Journal	Physiology
Volume	34
Issue number	1
DOIs	https://doi.org/10.1152/physiol.00038.2018
Publication status	Published - 1 Jan 2019

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10.1152/physiol.00038.2018

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High-Intensity Exercise and Mitochondrial Biogenesis : Current Controversies and Future Research Directions. / Bishop, David J.; Botella, Javier; Genders, Amanda J.; Lee, Matthew J.C.; Saner, Nicholas J.; Kuang, Jujiao; Yan, Xu; Granata, Cesare.

In: Physiology, Vol. 34, No. 1, 01.01.2019, p. 56-70.

Research output: Contribution to journal › Review Article › Research › peer-review

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AU - Bishop, David J.

AU - Botella, Javier

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AU - Saner, Nicholas J.

AU - Kuang, Jujiao

AU - Yan, Xu

AU - Granata, Cesare

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AB - It is well established that different types of exercise can provide a powerful stimulus for mitochondrial biogenesis. However, there are conflicting findings in the literature, and a consensus has not been reached regarding the efficacy of high-intensity exercise to promote mitochondrial biogenesis in humans. The purpose of this review is to examine current controversies in the field and to highlight some important methodological issues that need to be addressed to resolve existing conflicts.

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High-Intensity Exercise and Mitochondrial Biogenesis: Current Controversies and Future Research Directions

Abstract

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Ramaciotti Centre for Cryo-Electron Microscopy

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