High incidence of Pneumocystis jirovecii pneumonia in patients receiving biweekly rituximab and cyclophosphamide, adriamycin, vincristine, and prednisone

Sarah Kamel, Shaun O'Connor, Newton Lee, Robin J A Filshie, Harshal Hanumant Nandurkar, Constantine S Tam

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Abstract

The risk of infection with Pneumocystis jirovecii pneumonia (PCP) in patients undergoing chemotherapy is closely related to the intensity of corticosteroid exposure. PCP is uncommon with classical (3-weekly) R-CHOP, but the risk may be higher with biweekly R-CHOP (R-CHOP-14) due to the increased frequency of prednisolone pulses. Among 47 consecutive patients treated with R-CHOP-14 at our institution, five (11) developed microbiologically proven PCP, with a further two (4) having classical clinical and radiological features of PCP, but without microbiological confirmation. None of these patients were HIV-positive or had additional risk factors for PCP. Our experience suggests that PCP prophylaxis should be considered in institutions using R-CHOP-14 for the treatment of patients with aggressive lymphomas.
Original languageEnglish
Pages (from-to)797 - 801
Number of pages5
JournalLeukemia and Lymphoma
Volume51
Issue number5
DOIs
Publication statusPublished - 2010
Externally publishedYes

Cite this