High fat diet is not associated with stimulation of colorectal cancer liver metastases

Jurstine Daruwalla, Andrew Hadj, Shu Wen Wen, Theodora Fifis, Eunice Yang, Linh Nguyen, Christopher Christophi, Mehrdad Nikfarjam

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: A high fat diet induces fatty infiltration of visceral organs and has been associated with the development of some cancers and may influence the progression and spread of cancer.The impact of high fat diet on the growth and development colorectal liver metastases is uncertain.
Methodology: Liver metastases were induced in CBA mice using a murine derived colon cancer cell line by intrasplenic injection. Mice were fed either a high fat (60% fat content) (n = 20) or low fat diet (5% fat content) (n = 20) for 6 weeks prior tumor induction and maintained on the same diet thereafter. Tumor volume and patterns of spread were assessed at day 21 post induction. Tumor necrosis, apoptosis and proliferation were assessed using immunohistochemistry.
Results: No difference in liver metastases, tumor necrosis or apoptosis was observed between the two groups. There was a trend towards increased tumor proliferation in the high fat diet group.
Conclusions: A high fat diet alone did not induce tumor stimulation and progression of colorectal liver metastases. Several studies have alluded to the deregulation of catabolic cytokines present in malignancy in the obese state and this may explain the negligible effects of a high fat diet.
Original languageEnglish
Pages (from-to)30 - 38
Number of pages9
JournalWorld Journal of Surgical Research
Volume3
Issue number5
Publication statusPublished - 2014
Externally publishedYes

Cite this

Daruwalla, J., Hadj, A., Wen, S. W., Fifis, T., Yang, E., Nguyen, L., ... Nikfarjam, M. (2014). High fat diet is not associated with stimulation of colorectal cancer liver metastases. World Journal of Surgical Research, 3(5), 30 - 38.
Daruwalla, Jurstine ; Hadj, Andrew ; Wen, Shu Wen ; Fifis, Theodora ; Yang, Eunice ; Nguyen, Linh ; Christophi, Christopher ; Nikfarjam, Mehrdad. / High fat diet is not associated with stimulation of colorectal cancer liver metastases. In: World Journal of Surgical Research. 2014 ; Vol. 3, No. 5. pp. 30 - 38.
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title = "High fat diet is not associated with stimulation of colorectal cancer liver metastases",
abstract = "Background: A high fat diet induces fatty infiltration of visceral organs and has been associated with the development of some cancers and may influence the progression and spread of cancer.The impact of high fat diet on the growth and development colorectal liver metastases is uncertain.Methodology: Liver metastases were induced in CBA mice using a murine derived colon cancer cell line by intrasplenic injection. Mice were fed either a high fat (60{\%} fat content) (n = 20) or low fat diet (5{\%} fat content) (n = 20) for 6 weeks prior tumor induction and maintained on the same diet thereafter. Tumor volume and patterns of spread were assessed at day 21 post induction. Tumor necrosis, apoptosis and proliferation were assessed using immunohistochemistry.Results: No difference in liver metastases, tumor necrosis or apoptosis was observed between the two groups. There was a trend towards increased tumor proliferation in the high fat diet group.Conclusions: A high fat diet alone did not induce tumor stimulation and progression of colorectal liver metastases. Several studies have alluded to the deregulation of catabolic cytokines present in malignancy in the obese state and this may explain the negligible effects of a high fat diet.",
author = "Jurstine Daruwalla and Andrew Hadj and Wen, {Shu Wen} and Theodora Fifis and Eunice Yang and Linh Nguyen and Christopher Christophi and Mehrdad Nikfarjam",
year = "2014",
language = "English",
volume = "3",
pages = "30 -- 38",
journal = "World Journal of Surgical Research",
issn = "2278-3210",
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Daruwalla, J, Hadj, A, Wen, SW, Fifis, T, Yang, E, Nguyen, L, Christophi, C & Nikfarjam, M 2014, 'High fat diet is not associated with stimulation of colorectal cancer liver metastases', World Journal of Surgical Research, vol. 3, no. 5, pp. 30 - 38.

High fat diet is not associated with stimulation of colorectal cancer liver metastases. / Daruwalla, Jurstine ; Hadj, Andrew ; Wen, Shu Wen; Fifis, Theodora; Yang, Eunice; Nguyen, Linh; Christophi, Christopher; Nikfarjam, Mehrdad.

In: World Journal of Surgical Research, Vol. 3, No. 5, 2014, p. 30 - 38.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - High fat diet is not associated with stimulation of colorectal cancer liver metastases

AU - Daruwalla, Jurstine

AU - Hadj, Andrew

AU - Wen, Shu Wen

AU - Fifis, Theodora

AU - Yang, Eunice

AU - Nguyen, Linh

AU - Christophi, Christopher

AU - Nikfarjam, Mehrdad

PY - 2014

Y1 - 2014

N2 - Background: A high fat diet induces fatty infiltration of visceral organs and has been associated with the development of some cancers and may influence the progression and spread of cancer.The impact of high fat diet on the growth and development colorectal liver metastases is uncertain.Methodology: Liver metastases were induced in CBA mice using a murine derived colon cancer cell line by intrasplenic injection. Mice were fed either a high fat (60% fat content) (n = 20) or low fat diet (5% fat content) (n = 20) for 6 weeks prior tumor induction and maintained on the same diet thereafter. Tumor volume and patterns of spread were assessed at day 21 post induction. Tumor necrosis, apoptosis and proliferation were assessed using immunohistochemistry.Results: No difference in liver metastases, tumor necrosis or apoptosis was observed between the two groups. There was a trend towards increased tumor proliferation in the high fat diet group.Conclusions: A high fat diet alone did not induce tumor stimulation and progression of colorectal liver metastases. Several studies have alluded to the deregulation of catabolic cytokines present in malignancy in the obese state and this may explain the negligible effects of a high fat diet.

AB - Background: A high fat diet induces fatty infiltration of visceral organs and has been associated with the development of some cancers and may influence the progression and spread of cancer.The impact of high fat diet on the growth and development colorectal liver metastases is uncertain.Methodology: Liver metastases were induced in CBA mice using a murine derived colon cancer cell line by intrasplenic injection. Mice were fed either a high fat (60% fat content) (n = 20) or low fat diet (5% fat content) (n = 20) for 6 weeks prior tumor induction and maintained on the same diet thereafter. Tumor volume and patterns of spread were assessed at day 21 post induction. Tumor necrosis, apoptosis and proliferation were assessed using immunohistochemistry.Results: No difference in liver metastases, tumor necrosis or apoptosis was observed between the two groups. There was a trend towards increased tumor proliferation in the high fat diet group.Conclusions: A high fat diet alone did not induce tumor stimulation and progression of colorectal liver metastases. Several studies have alluded to the deregulation of catabolic cytokines present in malignancy in the obese state and this may explain the negligible effects of a high fat diet.

M3 - Article

VL - 3

SP - 30

EP - 38

JO - World Journal of Surgical Research

JF - World Journal of Surgical Research

SN - 2278-3210

IS - 5

ER -