High-dose thiotepa, etoposide and carboplatin as conditioning regimen for autologous stem cell transplantation in patients with high-risk Hodgkin's lymphoma

Mauro Di Ianni, Stelvio Ballanti, Giuseppe Iodice, Antonia Reale, Franca Falzetti, Olivia Minelli, Gabriella Serio, Massimo F. Martelli, Franco Dammacco, Angelo Vacca, Roberto Ria

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13 Citations (Scopus)

Abstract

Background: Autologous stem cell transplantation (ASCT) generally provides good results in Hodgkin's lymphoma (HL). We studied a high-dose chemotherapy regimen based on thiotepa, etoposide and carboplatin (TECA). Methods: Fifty-eight patients with advanced HL were treated with thiotepa, etoposide and carbo platin for transplant induction. Results: The overall response rate was 79.3% (39 CR: 67.2%; and 7 PR: 12.1%); 12 patients (20.1%) were non-responders. The 5-year overall survival rate was 77.6%; five initially responder patients relapsed within the first 5 years of follow-up and underwent salvage therapy. Conclusion: The TECA conditioning regimen for ASCT in HL results in a good anti-HL effect, positive response to treatment and high 5-year overall survival rate. It was also well tolerated and did not induce excessive toxicity, suggesting that TECA may be a very useful conditioning regimen for HL.

Original languageEnglish
Pages (from-to)23-27
Number of pages5
JournalHematology
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 2012
Externally publishedYes

Keywords

  • Autologous stem cell transplantation
  • Conditioning regimen
  • High-dose chemotherapy
  • Hodgkin's lymphoma
  • Survival

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