High-density lipoprotein mimetics: Promises and challenges

Dmitri Sviridov, Alan T. Remaley

Research output: Contribution to journalReview ArticleResearchpeer-review

15 Citations (Scopus)

Abstract

The concept of lipoprotein mimetics was developed and extensively tested in the last three decades. Most lipoprotein mimetics were designed to recreate one or several functions of high-density lipoprotein (HDL) in the context of cardiovascular disease; however, the application of this approach is much broader. Lipoprotein mimetics should not just be seen as a set of compounds aimed at replenishing a deficiency or dysfunctionality of individual elements of lipoproteinmetabolism but rather as a designer concept with remarkable flexibility and numerous applications in medicine and biology. In the present review, we discuss the fundamental design principles used to create lipoprotein mimetics, mechanisms of their action, medical indications and efficacy in animal models and human studies.

Original languageEnglish
Pages (from-to)249-259
Number of pages11
JournalBiochemical Journal
Volume472
Issue number3
DOIs
Publication statusPublished - 27 Nov 2015
Externally publishedYes

Keywords

  • Apolipoproteins
  • Atherosclerosis
  • Cholesterolmetabolism
  • Lipoprotein metabolism
  • Peptides.

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