High-Density Lipoprotein Infusions

Kohei Takata, Belinda A. Di Bartolo, Stephen J. Nicholls

Research output: Contribution to journalReview ArticleOtherpeer-review

1 Citation (Scopus)

Abstract

High-density lipoproteins (HDLs) have presented an attractive target for development of new therapies for cardiovascular prevention on the basis of epidemiology and preclinical studies demonstrating their protective properties. Development of HDL mimetics provides an opportunity to administer functional HDL. However, clinical trials have produced variable results, with no evidence to date that they reduce cardiovascular events. This article reviews development programs of HDL mimetics.

Original languageEnglish
Pages (from-to)311-315
Number of pages5
JournalCardiology Clinics
Volume36
Issue number2
DOIs
Publication statusPublished - 1 May 2018
Externally publishedYes

Keywords

  • Atherosclerosis
  • Cardiovascular risk
  • High-density lipoproteins
  • Lipids

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