High consumption of Ω-3 polyunsaturated fatty acids decrease plasma homocysteine: A meta-analysis of randomized, placebo-controlled trials

Tao Huang, Jusheng Zheng, Ying Chen, Bin Yang, Mark L. Wahlqvist, Duo Li

    Research output: Contribution to journalReview ArticleResearchpeer-review

    46 Citations (Scopus)


    Objective: High consumption of ω-3 polyunsaturated fatty acids (PUFAs) has been associated with lower plasma homocystine (Hcy) levels, but intervention studies in humans have been inconclusive. The objective was to systematically evaluate the effects of ω-3 PUFA supplementation on plasma Hcy levels. Methods: A comprehensive search of Medline, EMBASE, the Cochrane Clinical Trials Registry, and bibliographies of relevant articles published from 1966 through September 2010 was undertaken. All randomized, placebo-controlled trials that compared ω-3 PUFA supplementation with placebo were included. Two investigators performed data extraction and quality scoring independently, with discrepancies resolved by consensus. Results: Eleven trials including 702 subjects were analyzed. The outcomes studied were plasma Hcy level. Eleven randomized, placebo-controlled trials were included in this meta-analysis. Supplementation with ω-3 PUFAs was associated with a significant decrease in plasma Hcy level (weighted mean difference -1.59 μmol/L, 95% confidence interval -2.34 to -0.83) compared with control subjects. Conclusion: This meta-analysis suggested that ω-3 PUFA supplementation can decrease plasma Hcy levels. The implications of these findings remain to be elucidated.

    Original languageEnglish
    Pages (from-to)863-867
    Number of pages5
    Issue number9
    Publication statusPublished - Sept 2011


    • ω-3 Polyunsaturated fatty acid
    • Fish oil
    • Homocysteine
    • Meta-analysis
    • Randomized, placebo-controlled trials

    Cite this