High consumption of Ω-3 polyunsaturated fatty acids decrease plasma homocysteine

A meta-analysis of randomized, placebo-controlled trials

Tao Huang, Jusheng Zheng, Ying Chen, Bin Yang, Mark L. Wahlqvist, Duo Li

Research output: Contribution to journalReview ArticleResearchpeer-review

33 Citations (Scopus)

Abstract

Objective: High consumption of ω-3 polyunsaturated fatty acids (PUFAs) has been associated with lower plasma homocystine (Hcy) levels, but intervention studies in humans have been inconclusive. The objective was to systematically evaluate the effects of ω-3 PUFA supplementation on plasma Hcy levels. Methods: A comprehensive search of Medline, EMBASE, the Cochrane Clinical Trials Registry, and bibliographies of relevant articles published from 1966 through September 2010 was undertaken. All randomized, placebo-controlled trials that compared ω-3 PUFA supplementation with placebo were included. Two investigators performed data extraction and quality scoring independently, with discrepancies resolved by consensus. Results: Eleven trials including 702 subjects were analyzed. The outcomes studied were plasma Hcy level. Eleven randomized, placebo-controlled trials were included in this meta-analysis. Supplementation with ω-3 PUFAs was associated with a significant decrease in plasma Hcy level (weighted mean difference -1.59 μmol/L, 95% confidence interval -2.34 to -0.83) compared with control subjects. Conclusion: This meta-analysis suggested that ω-3 PUFA supplementation can decrease plasma Hcy levels. The implications of these findings remain to be elucidated.

Original languageEnglish
Pages (from-to)863-867
Number of pages5
JournalNutrition
Volume27
Issue number9
DOIs
Publication statusPublished - Sep 2011

Keywords

  • ω-3 Polyunsaturated fatty acid
  • Fish oil
  • Homocysteine
  • Meta-analysis
  • Randomized, placebo-controlled trials

Cite this

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title = "High consumption of Ω-3 polyunsaturated fatty acids decrease plasma homocysteine: A meta-analysis of randomized, placebo-controlled trials",
abstract = "Objective: High consumption of ω-3 polyunsaturated fatty acids (PUFAs) has been associated with lower plasma homocystine (Hcy) levels, but intervention studies in humans have been inconclusive. The objective was to systematically evaluate the effects of ω-3 PUFA supplementation on plasma Hcy levels. Methods: A comprehensive search of Medline, EMBASE, the Cochrane Clinical Trials Registry, and bibliographies of relevant articles published from 1966 through September 2010 was undertaken. All randomized, placebo-controlled trials that compared ω-3 PUFA supplementation with placebo were included. Two investigators performed data extraction and quality scoring independently, with discrepancies resolved by consensus. Results: Eleven trials including 702 subjects were analyzed. The outcomes studied were plasma Hcy level. Eleven randomized, placebo-controlled trials were included in this meta-analysis. Supplementation with ω-3 PUFAs was associated with a significant decrease in plasma Hcy level (weighted mean difference -1.59 μmol/L, 95{\%} confidence interval -2.34 to -0.83) compared with control subjects. Conclusion: This meta-analysis suggested that ω-3 PUFA supplementation can decrease plasma Hcy levels. The implications of these findings remain to be elucidated.",
keywords = "ω-3 Polyunsaturated fatty acid, Fish oil, Homocysteine, Meta-analysis, Randomized, placebo-controlled trials",
author = "Tao Huang and Jusheng Zheng and Ying Chen and Bin Yang and Wahlqvist, {Mark L.} and Duo Li",
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High consumption of Ω-3 polyunsaturated fatty acids decrease plasma homocysteine : A meta-analysis of randomized, placebo-controlled trials. / Huang, Tao; Zheng, Jusheng; Chen, Ying; Yang, Bin; Wahlqvist, Mark L.; Li, Duo.

In: Nutrition, Vol. 27, No. 9, 09.2011, p. 863-867.

Research output: Contribution to journalReview ArticleResearchpeer-review

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