Hierarchical biointerfaces assembled by leukocyte-inspired particles for specifically recognizing cancer cells

Jingxin Meng; Hongliang Liu; Xueli Liu; Gao Yang; Pengchao Zhang; Shutao Wang; Lei Jiang

doi:10.1002/smll.201400215

Hierarchical biointerfaces assembled by leukocyte-inspired particles for specifically recognizing cancer cells

Jingxin Meng, Hongliang Liu, Xueli Liu, Gao Yang, Pengchao Zhang, Shutao Wang, Lei Jiang

Research output: Contribution to journal › Article › Research › peer-review

39 Citations (Scopus)

Abstract

By mimicking certain biochemical and physical attributes of biological cells, bioinspired particles have attracted great attention for potential biomedical applications based on cell-like biological functions. Inspired by leukocytes, hierarchical biointerfaces are designed and prepared based on specifi c molecules-modifi ed leukocyte-inspired particles. These biointerfaces can effi ciently recognize cancer cells from whole blood samples through the synergistic effect of molecular recognition and topographical interaction. Compared to fl at, mono-micro or nano-biointerfaces, these micro/nano hierarchical biointerfaces are better able to promote specifi c recognition interactions, resulting in an enhanced cell-capture effi ciency. It is anticipated that this study may provide promising guidance to develop new bio-inspired hierarchical biointerfaces for biomedical applications.

Original language	English
Pages (from-to)	3735-3741
Number of pages	7
Journal	Small
Volume	10
Issue number	18
DOIs	https://doi.org/10.1002/smll.201400215
Publication status	Published - 24 Sept 2014
Externally published	Yes

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10.1002/smll.201400215

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abstract = "By mimicking certain biochemical and physical attributes of biological cells, bioinspired particles have attracted great attention for potential biomedical applications based on cell-like biological functions. Inspired by leukocytes, hierarchical biointerfaces are designed and prepared based on specifi c molecules-modifi ed leukocyte-inspired particles. These biointerfaces can effi ciently recognize cancer cells from whole blood samples through the synergistic effect of molecular recognition and topographical interaction. Compared to fl at, mono-micro or nano-biointerfaces, these micro/nano hierarchical biointerfaces are better able to promote specifi c recognition interactions, resulting in an enhanced cell-capture effi ciency. It is anticipated that this study may provide promising guidance to develop new bio-inspired hierarchical biointerfaces for biomedical applications.",

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AU - Meng, Jingxin

AU - Liu, Hongliang

AU - Liu, Xueli

AU - Yang, Gao

AU - Zhang, Pengchao

AU - Wang, Shutao

AU - Jiang, Lei

PY - 2014/9/24

Y1 - 2014/9/24

N2 - By mimicking certain biochemical and physical attributes of biological cells, bioinspired particles have attracted great attention for potential biomedical applications based on cell-like biological functions. Inspired by leukocytes, hierarchical biointerfaces are designed and prepared based on specifi c molecules-modifi ed leukocyte-inspired particles. These biointerfaces can effi ciently recognize cancer cells from whole blood samples through the synergistic effect of molecular recognition and topographical interaction. Compared to fl at, mono-micro or nano-biointerfaces, these micro/nano hierarchical biointerfaces are better able to promote specifi c recognition interactions, resulting in an enhanced cell-capture effi ciency. It is anticipated that this study may provide promising guidance to develop new bio-inspired hierarchical biointerfaces for biomedical applications.

AB - By mimicking certain biochemical and physical attributes of biological cells, bioinspired particles have attracted great attention for potential biomedical applications based on cell-like biological functions. Inspired by leukocytes, hierarchical biointerfaces are designed and prepared based on specifi c molecules-modifi ed leukocyte-inspired particles. These biointerfaces can effi ciently recognize cancer cells from whole blood samples through the synergistic effect of molecular recognition and topographical interaction. Compared to fl at, mono-micro or nano-biointerfaces, these micro/nano hierarchical biointerfaces are better able to promote specifi c recognition interactions, resulting in an enhanced cell-capture effi ciency. It is anticipated that this study may provide promising guidance to develop new bio-inspired hierarchical biointerfaces for biomedical applications.

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Hierarchical biointerfaces assembled by leukocyte-inspired particles for specifically recognizing cancer cells

Abstract

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