Abstract
Objective: To assess multicentre, randomised, controlled trials (MC-RCTs) of systemic inflammatory response syndrome (SIRS) and sepsis conducted in Japan, published in Japanese and not available to English-language medical databases. Design: Methodological review. Subjects: All Japanese RCTs relevant to SIRS and sepsis. Intervention: Identification of manuscripts using a Japanese electronic library. Critical analysis of methodology and reporting quality using a modified Methodological Quality Assessment Score and the CONSORT group check list. Measurements and results: Three MC-RCTs were identified. In the first, 147 patients with septic shock were randomised to methylprednisolone (1000 mg i.v.) or placebo. In the second, 221 patients were randomised to 0.20 mg/kg per h or 0.004 mg/kg per h of sivelestat for acute lung injury with SIRS. In the third, 504 patients were randomised to immunoglobulin (5 g for 3 days) or to a control group. The average methodological quality score was higher than that of equivalent Western trials. The reporting quality (CONSORT checklist) was comparable to Western studies published during the same period. Conclusions: Despite sound methodology and quality, the information obtained from relatively large Japanese critical care trials is not widely available to English-speaking investigators and therefore might be ignored in meta-analyses.
| Original language | English |
|---|---|
| Pages (from-to) | 911-917 |
| Number of pages | 7 |
| Journal | Intensive Care Medicine |
| Volume | 30 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 May 2004 |
| Externally published | Yes |
Keywords
- Acute respiratory distress syndrome
- Evidence-based medicine
- Outcome
- Randomised, controlled trial
- Sepsis
- Systemic inflammatory response syndrome
Cite this
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Hidden evidence to the West : Multicentre, randomised, controlled trials in sepsis and systemic inflammatory response syndrome in Japanese journals. / Bellomo, Rinaldo; Uchino, Shigehiko; Naka, Toshio; Wan, Li.
In: Intensive Care Medicine, Vol. 30, No. 5, 01.05.2004, p. 911-917.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Hidden evidence to the West
T2 - Multicentre, randomised, controlled trials in sepsis and systemic inflammatory response syndrome in Japanese journals
AU - Bellomo, Rinaldo
AU - Uchino, Shigehiko
AU - Naka, Toshio
AU - Wan, Li
PY - 2004/5/1
Y1 - 2004/5/1
N2 - Objective: To assess multicentre, randomised, controlled trials (MC-RCTs) of systemic inflammatory response syndrome (SIRS) and sepsis conducted in Japan, published in Japanese and not available to English-language medical databases. Design: Methodological review. Subjects: All Japanese RCTs relevant to SIRS and sepsis. Intervention: Identification of manuscripts using a Japanese electronic library. Critical analysis of methodology and reporting quality using a modified Methodological Quality Assessment Score and the CONSORT group check list. Measurements and results: Three MC-RCTs were identified. In the first, 147 patients with septic shock were randomised to methylprednisolone (1000 mg i.v.) or placebo. In the second, 221 patients were randomised to 0.20 mg/kg per h or 0.004 mg/kg per h of sivelestat for acute lung injury with SIRS. In the third, 504 patients were randomised to immunoglobulin (5 g for 3 days) or to a control group. The average methodological quality score was higher than that of equivalent Western trials. The reporting quality (CONSORT checklist) was comparable to Western studies published during the same period. Conclusions: Despite sound methodology and quality, the information obtained from relatively large Japanese critical care trials is not widely available to English-speaking investigators and therefore might be ignored in meta-analyses.
AB - Objective: To assess multicentre, randomised, controlled trials (MC-RCTs) of systemic inflammatory response syndrome (SIRS) and sepsis conducted in Japan, published in Japanese and not available to English-language medical databases. Design: Methodological review. Subjects: All Japanese RCTs relevant to SIRS and sepsis. Intervention: Identification of manuscripts using a Japanese electronic library. Critical analysis of methodology and reporting quality using a modified Methodological Quality Assessment Score and the CONSORT group check list. Measurements and results: Three MC-RCTs were identified. In the first, 147 patients with septic shock were randomised to methylprednisolone (1000 mg i.v.) or placebo. In the second, 221 patients were randomised to 0.20 mg/kg per h or 0.004 mg/kg per h of sivelestat for acute lung injury with SIRS. In the third, 504 patients were randomised to immunoglobulin (5 g for 3 days) or to a control group. The average methodological quality score was higher than that of equivalent Western trials. The reporting quality (CONSORT checklist) was comparable to Western studies published during the same period. Conclusions: Despite sound methodology and quality, the information obtained from relatively large Japanese critical care trials is not widely available to English-speaking investigators and therefore might be ignored in meta-analyses.
KW - Acute respiratory distress syndrome
KW - Evidence-based medicine
KW - Outcome
KW - Randomised, controlled trial
KW - Sepsis
KW - Systemic inflammatory response syndrome
UR - http://www.scopus.com/inward/record.url?scp=2442567973&partnerID=8YFLogxK
U2 - 10.1007/s00134-004-2196-6
DO - 10.1007/s00134-004-2196-6
M3 - Review Article
C2 - 15052382
AN - SCOPUS:2442567973
VL - 30
SP - 911
EP - 917
JO - Intensive Care Medicine
JF - Intensive Care Medicine
SN - 0342-4642
IS - 5
ER -