HFE C282Y homozygosity is associated with an increased risk of total hip replacement for osteoarthritis

YuanYuan Wang; Lyle C Gurrin; Anita Wluka; Nadine Bertalli; Nicholas Osborne; Martin Delatycki; Graham Giles; Dallas English; John Hopper; Julie Simpson; Stephen Graves; Katrina Allen; Flavia Cicuttini

doi:10.1016/j.semarthrit.2011.11.003

HFE C282Y homozygosity is associated with an increased risk of total hip replacement for osteoarthritis

YuanYuan Wang, Lyle C Gurrin, Anita Wluka, Nadine Bertalli, Nicholas Osborne, Martin Delatycki, Graham Giles, Dallas English, John Hopper, Julie Simpson, Stephen Graves, Katrina Allen, Flavia Cicuttini

Epidemiology and Preventive Medicine Alfred Hospital

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Abstract

Objective: The evidence for an association between mutations in the HFE (hemochromatosis) gene and the risk of hip or knee osteoarthritis is inconsistent. Total joint replacement is considered a surrogate measure for symptomatic end-stage osteoarthritis. We examined the relationship between HFE gene mutations and risk of total hip and knee replacement using a prospective cohort study.

Methods: The Melbourne Collaborative Cohort Study recruited participants between 1990 and 1994. Participants born in Australia, New Zealand, the United Kingdom, or Ireland (n = 27,848) were genotyped for the HFE C282Y mutation. Total hip and knee replacements for osteoarthritis during 2001 to 2009 were ascertained from the Australian Orthopaedic Association National Joint Replacement Registry. Hazard ratios (HR)/odds ratios (OR) and confidence intervals (CI) were obtained from Cox regression or logistic regression.

Results: Compared with those with no C282Y mutation, C282Y homozygotes had an increased risk of single total hip replacement (HR 1.94, 95% CI 1.04-3.62) and bilateral total hip replacement (OR 5.86, 95% CI 2.36-14.57) for osteoarthritis, adjusting for age, sex, body mass index, and educational level. Only 3 C282Y homozygotes had single total knee replacement; the HR was 0.51 (95% CI 0.16-1.57). C282Y/H63D compound heterozygosity was not related to the risk of total hip or knee replacement.

Conclusions: HFE C282Y homozygosity was associated with an increased risk of both single and bilateral total hip replacement for osteoarthritis.

Original language	English
Pages (from-to)	872-878
Number of pages	7
Journal	Seminars in Arthritis and Rheumatism
Volume	41
Issue number	6
DOIs	https://doi.org/10.1016/j.semarthrit.2011.11.003
Publication status	Published - 2012

Access to Document

10.1016/j.semarthrit.2011.11.003

Is low dose amitriptyline more effective than placebo in the management of chronic, neuropathic low back pain? A double-blind, randomized, placebo-controlled trial with an economic evaluation
Urquhart, D., Forbes, A., Gibson, S., Sim, M., Wluka, A. & van Tulder, M. W.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/12 → 31/12/14
Project: Research

Cite this

Wang, Y., Gurrin, L. C., Wluka, A., Bertalli, N., Osborne, N., Delatycki, M., Giles, G., English, D., Hopper, J., Simpson, J., Graves, S., Allen, K., & Cicuttini, F. (2012). HFE C282Y homozygosity is associated with an increased risk of total hip replacement for osteoarthritis. Seminars in Arthritis and Rheumatism, 41(6), 872-878. https://doi.org/10.1016/j.semarthrit.2011.11.003

@article{c836626c5dd044c1921a1e5d30594c9b,

title = "HFE C282Y homozygosity is associated with an increased risk of total hip replacement for osteoarthritis",

abstract = "Objective: The evidence for an association between mutations in the HFE (hemochromatosis) gene and the risk of hip or knee osteoarthritis is inconsistent. Total joint replacement is considered a surrogate measure for symptomatic end-stage osteoarthritis. We examined the relationship between HFE gene mutations and risk of total hip and knee replacement using a prospective cohort study.Methods: The Melbourne Collaborative Cohort Study recruited participants between 1990 and 1994. Participants born in Australia, New Zealand, the United Kingdom, or Ireland (n = 27,848) were genotyped for the HFE C282Y mutation. Total hip and knee replacements for osteoarthritis during 2001 to 2009 were ascertained from the Australian Orthopaedic Association National Joint Replacement Registry. Hazard ratios (HR)/odds ratios (OR) and confidence intervals (CI) were obtained from Cox regression or logistic regression.Results: Compared with those with no C282Y mutation, C282Y homozygotes had an increased risk of single total hip replacement (HR 1.94, 95% CI 1.04-3.62) and bilateral total hip replacement (OR 5.86, 95% CI 2.36-14.57) for osteoarthritis, adjusting for age, sex, body mass index, and educational level. Only 3 C282Y homozygotes had single total knee replacement; the HR was 0.51 (95% CI 0.16-1.57). C282Y/H63D compound heterozygosity was not related to the risk of total hip or knee replacement.Conclusions: HFE C282Y homozygosity was associated with an increased risk of both single and bilateral total hip replacement for osteoarthritis.",

author = "YuanYuan Wang and Gurrin, {Lyle C} and Anita Wluka and Nadine Bertalli and Nicholas Osborne and Martin Delatycki and Graham Giles and Dallas English and John Hopper and Julie Simpson and Stephen Graves and Katrina Allen and Flavia Cicuttini",

year = "2012",

doi = "10.1016/j.semarthrit.2011.11.003",

language = "English",

volume = "41",

pages = "872--878",

journal = "Seminars in Arthritis and Rheumatism",

issn = "0049-0172",

publisher = "Elsevier",

number = "6",

}

Wang, Y, Gurrin, LC, Wluka, A, Bertalli, N, Osborne, N, Delatycki, M, Giles, G, English, D, Hopper, J, Simpson, J, Graves, S, Allen, K & Cicuttini, F 2012, 'HFE C282Y homozygosity is associated with an increased risk of total hip replacement for osteoarthritis', Seminars in Arthritis and Rheumatism, vol. 41, no. 6, pp. 872-878. https://doi.org/10.1016/j.semarthrit.2011.11.003

TY - JOUR

T1 - HFE C282Y homozygosity is associated with an increased risk of total hip replacement for osteoarthritis

AU - Wang, YuanYuan

AU - Gurrin, Lyle C

AU - Wluka, Anita

AU - Bertalli, Nadine

AU - Osborne, Nicholas

AU - Delatycki, Martin

AU - Giles, Graham

AU - English, Dallas

AU - Hopper, John

AU - Simpson, Julie

AU - Graves, Stephen

AU - Allen, Katrina

AU - Cicuttini, Flavia

PY - 2012

Y1 - 2012

N2 - Objective: The evidence for an association between mutations in the HFE (hemochromatosis) gene and the risk of hip or knee osteoarthritis is inconsistent. Total joint replacement is considered a surrogate measure for symptomatic end-stage osteoarthritis. We examined the relationship between HFE gene mutations and risk of total hip and knee replacement using a prospective cohort study.Methods: The Melbourne Collaborative Cohort Study recruited participants between 1990 and 1994. Participants born in Australia, New Zealand, the United Kingdom, or Ireland (n = 27,848) were genotyped for the HFE C282Y mutation. Total hip and knee replacements for osteoarthritis during 2001 to 2009 were ascertained from the Australian Orthopaedic Association National Joint Replacement Registry. Hazard ratios (HR)/odds ratios (OR) and confidence intervals (CI) were obtained from Cox regression or logistic regression.Results: Compared with those with no C282Y mutation, C282Y homozygotes had an increased risk of single total hip replacement (HR 1.94, 95% CI 1.04-3.62) and bilateral total hip replacement (OR 5.86, 95% CI 2.36-14.57) for osteoarthritis, adjusting for age, sex, body mass index, and educational level. Only 3 C282Y homozygotes had single total knee replacement; the HR was 0.51 (95% CI 0.16-1.57). C282Y/H63D compound heterozygosity was not related to the risk of total hip or knee replacement.Conclusions: HFE C282Y homozygosity was associated with an increased risk of both single and bilateral total hip replacement for osteoarthritis.

AB - Objective: The evidence for an association between mutations in the HFE (hemochromatosis) gene and the risk of hip or knee osteoarthritis is inconsistent. Total joint replacement is considered a surrogate measure for symptomatic end-stage osteoarthritis. We examined the relationship between HFE gene mutations and risk of total hip and knee replacement using a prospective cohort study.Methods: The Melbourne Collaborative Cohort Study recruited participants between 1990 and 1994. Participants born in Australia, New Zealand, the United Kingdom, or Ireland (n = 27,848) were genotyped for the HFE C282Y mutation. Total hip and knee replacements for osteoarthritis during 2001 to 2009 were ascertained from the Australian Orthopaedic Association National Joint Replacement Registry. Hazard ratios (HR)/odds ratios (OR) and confidence intervals (CI) were obtained from Cox regression or logistic regression.Results: Compared with those with no C282Y mutation, C282Y homozygotes had an increased risk of single total hip replacement (HR 1.94, 95% CI 1.04-3.62) and bilateral total hip replacement (OR 5.86, 95% CI 2.36-14.57) for osteoarthritis, adjusting for age, sex, body mass index, and educational level. Only 3 C282Y homozygotes had single total knee replacement; the HR was 0.51 (95% CI 0.16-1.57). C282Y/H63D compound heterozygosity was not related to the risk of total hip or knee replacement.Conclusions: HFE C282Y homozygosity was associated with an increased risk of both single and bilateral total hip replacement for osteoarthritis.

U2 - 10.1016/j.semarthrit.2011.11.003

DO - 10.1016/j.semarthrit.2011.11.003

M3 - Article

SN - 0049-0172

VL - 41

SP - 872

EP - 878

JO - Seminars in Arthritis and Rheumatism

JF - Seminars in Arthritis and Rheumatism

IS - 6

ER -

HFE C282Y homozygosity is associated with an increased risk of total hip replacement for osteoarthritis

Abstract

Access to Document

Projects

Is low dose amitriptyline more effective than placebo in the management of chronic, neuropathic low back pain? A double-blind, randomized, placebo-controlled trial with an economic evaluation

Cite this