Heuristic modeling and 3D stereoscopic visualization of a Chlamydomonas reinhardtii cell

Niklas Biere, Mehmood Ghaffar, Anja Doebbe, Daniel Jäger, Nils Rothe, Benjamin M. Friedrich, Ralf Hofestädt, Falk Schreiber, Olaf Kruse, Björn Sommer

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

The structural modeling and representation of cells is a complex task as different microscopic, spectroscopic and other information resources have to be combined to achieve a three-dimensional representation with high accuracy. Moreover, to provide an appropriate spatial representation of the cell, a stereoscopic 3D (S3D) visualization is favorable. In this work, a structural cell model is created by combining information from various light microscopic and electron microscopic images as well as from publication-related data. At the mesoscopic level each cell component is presented with special structural and visual properties; at the molecular level a cell membrane composition and the underlying modeling method are discussed; and structural information is correlated with those at the functional level (represented by simplified energy-producing metabolic pathways). The organism used as an example is the unicellular Chlamydomonas reinhardtii, which might be important in future alternative energy production processes. Based on the 3D model, an educative S3D animation was created which was shown at conferences. The complete workflow was accomplished by using the open source 3D modeling software Blender. The discussed project including the animation is available from: http://Cm5.CELLmicrocosmos.org.

Original languageEnglish
Number of pages22
JournalJournal of integrative bioinformatics
Volume15
Issue number2
DOIs
Publication statusPublished - 11 Jul 2018

Keywords

  • Cell Modeling and Visualization
  • Computational Biology
  • Microscopic Imaging

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