Projects per year
Abstract
A previously-described live, attenuated vaccine (M1352, serovar Manilae, serogroup Pyrogenes) was tested in the hamster model of infection for cross-protective immunity. The vaccine elicited strong, significant cross-protection against lethal infection by strains representing four serologically distinct leptospiral serovars (Grippotyphosa, Australis, Canicola, and Autumnalis). Combined with our previously reported protection against serovars Pomona and Manilae, this work demonstrates unequivocal proof of concept for cross-protective immunity in leptospirosis.
Original language | English |
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Pages (from-to) | 47-50 |
Number of pages | 4 |
Journal | Veterinary Microbiology |
Volume | 223 |
DOIs | |
Publication status | Published - 1 Sept 2018 |
Keywords
- Cross-protection
- Leptospirosis
- Live vaccine
- Serovar
Projects
- 1 Finished
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Analysis and regulation of leptospiral virulence factors
National Health and Medical Research Council (NHMRC) (Australia)
5/01/09 → 31/12/12
Project: Research