This study aimed to express two major drug-metabolizing human hepatic cytochromes P450 (CYPs), CYP2D6 and CYP3A4, together with NADPH-cytochrome P450 oxidoreductase (OxR) in Escherichia coli and to evaluate their catalytic activities.
Pan, Y., Abd-Rashid, B. A., Ismail, Z., Ismail, R., Mak, J. W., & Ong, C. E. (2011). Heterologous expression of human cytochromes P450 2D6 and CYP3A4 in Escherichia coli and their functional characterization. Protein Journal, 30(3), 581 - 591. https://doi.org/10.1007/s10930-011-9365-6