Heterologous expression of human cytochromes P450 2D6 and CYP3A4 in Escherichia coli and their functional characterization

Yan Pan, Badrul Amini Abd-Rashid, Zakiah Ismail, Rusli Ismail, Joon Wah Mak, Chin Eng Ong

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    17 Citations (Scopus)

    Abstract

    This study aimed to express two major drug-metabolizing human hepatic cytochromes P450 (CYPs), CYP2D6 and CYP3A4, together with NADPH-cytochrome P450 oxidoreductase (OxR) in Escherichia coli and to evaluate their catalytic activities.
    Original languageEnglish
    Pages (from-to)581 - 591
    Number of pages11
    JournalProtein Journal
    Volume30
    Issue number3
    DOIs
    Publication statusPublished - 2011

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