Abstract
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.
Original language | English |
---|---|
Article number | e60060 |
Number of pages | 35 |
Journal | eLife |
Volume | 10 |
DOIs | |
Publication status | Published - Mar 2021 |
Externally published | Yes |
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In: eLife, Vol. 10, e60060, 03.2021.
Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight
AU - Iurilli, Maria L.C.
AU - Zhou, Bin
AU - Bennett, James E.
AU - Carrillo-Larco, Rodrigo M.
AU - Sophiea, Marisa K.
AU - Rodriguez-Martinez, Andrea
AU - Bixby, Honor
AU - Solomon, Bethlehem D.
AU - Taddei, Cristina
AU - Danaei, Goodarz
AU - Di Cesare, Mariachiara
AU - Stevens, Gretchen A.
AU - Riley, Leanne M.
AU - Savin, Stefan
AU - Cowan, Melanie J.
AU - Bovet, Pascal
AU - Damasceno, Albertino
AU - Chirita-Emandi, Adela
AU - Hayes, Alison J.
AU - Ikeda, Nayu
AU - Jackson, Rod T.
AU - Khang, Young Ho
AU - Laxmaiah, Avula
AU - Liu, Jing
AU - Miranda, J. Jaime
AU - Saidi, Olfa
AU - Sebert, Sylvain
AU - Sorić, Maroje
AU - Starc, Gregor
AU - Gregg, Edward W.
AU - Abarca-Gómez, Leandra
AU - Abdeen, Ziad A.
AU - Abdrakhmanova, Shynar
AU - Ghaffar, Suhaila Abdul
AU - Rahim, Hanan F.Abdul
AU - Abu-Rmeileh, Niveen M.
AU - Garba, Jamila Abubakar
AU - Acosta-Cazares, Benjamin
AU - Adams, Robert J.
AU - Aekplakorn, Wichai
AU - Afsana, Kaosar
AU - Afzal, Shoaib
AU - Agdeppa, Imelda A.
AU - Aghazadeh-Attari, Javad
AU - Aguilar-Salinas, Carlos A.
AU - Agyemang, Charles
AU - Ahmad, Mohamad Hasnan
AU - Ahmad, Noor Ani
AU - Ahmadi, Ali
AU - Ahmadi, Naser
AU - Ahmed, Soheir H.
AU - Ahrens, Wolfgang
AU - Aitmurzaeva, Gulmira
AU - Ajlouni, Kamel
AU - Al-Hazzaa, Hazzaa M.
AU - Al-Lahou, Badreya
AU - Al-Raddadi, Rajaa
AU - Alarouj, Monira
AU - AlBuhairan, Fadia
AU - AlDhukair, Shahla
AU - Ali, Mohamed M.
AU - Alkandari, Abdullah
AU - Alkerwi, Aláa
AU - Allin, Kristine
AU - Alvarez-Pedrerol, Mar
AU - Aly, Eman
AU - Amarapurkar, Deepak N.
AU - Amiri, Parisa
AU - Amougou, Norbert
AU - Amouyel, Philippe
AU - Andersen, Lars Bo
AU - Anderssen, Sigmund A.
AU - Ängquist, Lars
AU - Anjana, Ranjit Mohan
AU - Ansari-Moghaddam, Alireza
AU - Aounallah-Skhiri, Hajer
AU - Araújo, Joana
AU - Ariansen, Inger
AU - Aris, Tahir
AU - Arku, Raphael E.
AU - Arlappa, Nimmathota
AU - Aryal, Krishna K.
AU - Aspelund, Thor
AU - Assah, Felix K.
AU - Assunção, Maria Cecília F.
AU - Aung, May Soe
AU - Auvinen, Juha
AU - Mária Avdicová, Avdicová
AU - Avi, Shina
AU - Azevedo, Ana
AU - Azimi-Nezhad, Mohsen
AU - Azizi, Fereidoun
AU - Azmin, Mehrdad
AU - Babu, Bontha V.
AU - Bæksgaard Jørgensen, Maja
AU - Baharudin, Azli
AU - Bahijri, Suhad
AU - Baker, Jennifer L.
AU - Balakrishna, Nagalla
AU - Bamoshmoosh, Mohamed
AU - Banach, Maciej
AU - Bandosz, Piotr
AU - Banegas, José R.
AU - Baran, Joanna
AU - Barbagallo, Carlo M.
AU - Barceló, Alberto
AU - Barkat, Amina
AU - Barros, Aluisio J.D.
AU - Barros, Mauro Virgílio Gomes
AU - Basit, Abdul
AU - Bastos, Joao Luiz D.
AU - Bata, Iqbal
AU - Batieha, Anwar M.
AU - Batista, Rosangela L.
AU - Battakova, Zhamilya
AU - Batyrbek, Assembekov
AU - Baur, Louise A.
AU - Beaglehole, Robert
AU - Bel-Serrat, Silvia
AU - Belavendra, Antonisamy
AU - Romdhane, Habiba Ben
AU - Benedics, Judith
AU - Benet, Mikhail
AU - Bergh, Ingunn Holden
AU - Berkinbayev, Salim
AU - Bernabe-Ortiz, Antonio
AU - Bernotiene, Gailute
AU - Bettiol, Heloísa
AU - Bezerra, Jorge
AU - Bhagyalaxmi, Aroor
AU - Bharadwaj, Sumit
AU - Bhargava, Santosh K.
AU - Bhutta, Zulfiqar A.
AU - Bi, Hongsheng
AU - Bi, Yufang
AU - Bia, Daniel
AU - Lele, Elysee Claude Bika
AU - Bikbov, Mukharram M.
AU - Bista, Bihungum
AU - Bjelica, Dusko J.
AU - Bjerregaard, Peter
AU - Bjertness, Espen
AU - Bjertness, Marius B.
AU - Björkelund, Cecilia
AU - Bloch, Katia V.
AU - Blokstra, Anneke
AU - Bo, Simona
AU - Bobak, Martin
AU - Boddy, Lynne M.
AU - Boehm, Bernhard O.
AU - Boeing, Heiner
AU - Boggia, Jose G.
AU - Bogova, Elena
AU - Boissonnet, Carlos P.
AU - Bojesen, Stig E.
AU - Bonaccio, Marialaura
AU - Bongard, Vanina
AU - Bonilla-Vargas, Alice
AU - Bopp, Matthias
AU - Borghs, Herman
AU - Braeckevelt, Lien
AU - Braeckman, Lutgart
AU - Bragt, Marjolijn C.E.
AU - Brajkovich, Imperia
AU - Branca, Francesco
AU - Breckenkamp, Juergen
AU - Breda, Joaõ
AU - Brenner, Hermann
AU - Brewster, Lizzy M.
AU - Brian, Garry R.
AU - Brinduse, Lacramioara
AU - Brophy, Sinead
AU - Bruno, Graziella
AU - Bueno-de-Mesquita, H. Bas
AU - Bugge, Anna
AU - Buoncristiano, Marta
AU - Burazeri, Genc
AU - Burns, Con
AU - de León, Antonio Cabrera
AU - Cacciottolo, Joseph
AU - Cai, Hui
AU - Cama, Tilema
AU - Cameron, Christine
AU - Camolas, José
AU - Can, Günay
AU - Candido, Ana Paula C.
AU - Cañete, Felicia
AU - Capanzana, Mario V.
AU - Capková, Nadezda
AU - Capuano, Eduardo
AU - Capuano, Vincenzo
AU - Cardol, Marloes
AU - Cardoso, Viviane C.
AU - Carlsson, Axel C.
AU - Carmuega, Esteban
AU - Carvalho, Joana
AU - Casajús, José A.
AU - Casanueva, Felipe F.
AU - Celikcan, Ertugrul
AU - Censi, Laura
AU - Cervantes-Loaiza, Marvin
AU - Cesar, Juraci A.
AU - Chamukuttan, Snehalatha
AU - Chan, Angelique W.
AU - Chan, Queenie
AU - Chaturvedi, Himanshu K.
AU - Chaturvedi, Nish
AU - Rahim, Norsyamlina Che Abdul
AU - Chee, Miao Li
AU - Chen, Chien Jen
AU - Chen, Fangfang
AU - Chen, Huashuai
AU - Chen, Shuohua
AU - Chen, Zhengming
AU - Cheng, Ching Yu
AU - Cheraghian, Bahman
AU - Chetrit, Angela
AU - Chikova-Iscener, Ekaterina
AU - Chiolero, Arnaud
AU - Chiou, Shu Ti
AU - Chirlaque, María Dolores
AU - Cho, Belong
AU - Christensen, Kaare
AU - Christofaro, Diego G.
AU - Chudek, Jerzy
AU - Cifkova, Renata
AU - Cilia, Michelle
AU - Cinteza, Eliza
AU - Claessens, Frank
AU - Clarke, Janine
AU - Clays, Els
AU - Cohen, Emmanuel
AU - Concin, Hans
AU - Confortin, Susana C.
AU - Cooper, Cyrus
AU - Coppinger, Tara C.
AU - Corpeleijn, Eva
AU - Costanzo, Simona
AU - Cottel, Dominique
AU - Cowell, Chris
AU - Craig, Cora L.
AU - Crampin, Amelia C.
AU - Crujeiras, Ana B.
AU - Csilla, Semánová
AU - Cucu, Alexandra M.
AU - Cui, Liufu
AU - Magliano, Dianna J.
AU - Shaw, Jonathan E.
AU - Tan, Eng Joo
AU - Wareham, Nicholas
AU - NCD Risk Factor Collaboration (NCD-RisC)
N1 - Funding Information: Banska Bystrica Regional Authority of Public Health, Banska Bystrica, Slovakia; Shina Avi: Tel-Aviv University, Tel-Aviv, Israel; Hebrew University of Jerusalem, Jerusalem, Israel; Ana Azevedo: University of Porto Medical School, Porto, Portugal; Mohsen Azimi-Nezhad: Neyshabur University of Medical Sciences, Neyshabur, Islamic Republic of Iran; Fereidoun Azizi: Research Institute for Endocrine Sciences, Tehran, Islamic Republic of Iran; Mehrdad Azmin: NonCommunicable Diseases Research Center, Tehran, Islamic Republic of Iran; Bontha V Babu: Indian Council of Medical Research, New Delhi, India; Maja Bæksgaard Jørgensen: National Institute of Public Health, Copenhagen, Denmark; Azli Baharudin: Ministry of Health, Kuala Lumpur, Malaysia; Suhad Bahijri: King Abdulaziz University, Jeddah, Saudi Arabia; Jennifer L Baker: Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Nagalla Balakrishna: ICMR - National Institute of Nutrition, Hyderabad, India; Mohamed Bamoshmoosh: University of Science and Technology, Sana’a, Yemen; Maciej Banach: Medical University of Lodz, Lodz, Poland; Piotr Bandosz: Medical University of Gdansk, Gdansk, Poland; José R Banegas: Universidad Autónoma de Madrid CIBERESP, Madrid, Spain; Joanna Baran: University of Rzeszów, Rzeszów, Poland; Carlo M Barbagallo: University of Palermo, Palermo, Italy; Alberto Barceló: Pan American Health Organization, Washington DC, United States; Amina Barkat: Mohammed V University de Rabat, Rabat, Morocco; Aluisio JD Barros: Federal University of Pelotas, Pelotas, Brazil; Mauro Virgílio Gomes Barros: University of Pernambuco, Recife, Brazil; Abdul Basit: Baqai Institute of Diabetology and Endocrinology, Karachi, Pakistan; Joao Luiz D Bastos: Federal University of Santa Catarina, Florianópolis, Brazil; Iqbal Bata: Dalhousie University, Halifax, Canada; Anwar M Batieha: Jordan University of Science and Technology, Irbid, Jordan; Rosangela L Batista: Federal University of Maranhão, São Luís, Brazil; Zhamilya Battakova: National Center of Public Healthcare, Nur-Sultan, Kazakhstan; Assembekov Batyrbek: Al-Farabi Kazakh National University, Almaty, Kazakhstan; Louise A Baur: University of Sydney, Sydney, Australia; Robert Beaglehole: University of Auckland, Auckland, New Zealand; Silvia Bel-Serrat: University College Dublin, Dublin, Ireland; Antonisamy Belavendra: Christian Medical College, Vellore, India; Habiba Ben Romdhane: University Tunis El Manar, Tunis, Tunisia; Judith Benedics: Federal Ministry of Social Affairs, Health, Care and Consumer Protection, Vienna, Austria; Mikhail Benet: Cafam University Foundation, Bogota, Colombia; Ingunn Holden Bergh: Norwegian Institute of Public Health, Oslo, Norway; Salim Berkinbayev: Kazakh National Medical University, Almaty, Kazakhstan; Antonio Bernabe-Ortiz: Universidad Peruana Cayetano Heredia, Lima, Peru; Gailute Bernotiene: Lithuanian University of Health Sciences, Kaunas, Lithuania; Heloísa Bettiol: University of São Paulo, São Paulo, Brazil; Jorge Bezerra: University of Pernambuco, Recife, Brazil; Aroor Bhagyalaxmi: B J Medical College, Ahmedabad, India; Sumit Bharadwaj: Chirayu Medical College, New Delhi, India; Santosh K Bhargava: Sunder Lal Jain Hospital, Delhi, India; Zulfiqar A Bhutta: The Hospital for Sick Children, Toronto, Canada; Aga Khan University, Karachi, Pakistan; Hongsheng Bi: Shandong University of Traditional Chinese Medicine, Jinan, China; Yufang Bi: Shanghai Jiao-Tong University School of Medicine, Shanghai, China; Daniel Bia: Universidad de la República, Montevideo, Uruguay; Elysée Claude Bika Lele: Institute of Medical Research and Medicinal Plant Studies, Yaoundé, Cameroon; Mukharram M Bikbov: Ufa Eye Research Institute, Ufa, Russian Federation; Bihungum Bista: Nepal Health Research Council, Kathmandu, Nepal; Dusko J Bjelica: University of Montenegro, Niksic, Montenegro; Peter Bjerregaard: University of Southern Denmark, Copenhagen, Denmark; Espen Bjertness: University of Oslo, Oslo, Norway; Marius B Bjertness: University of Oslo, Oslo, Norway; Cecilia Björkelund: University of Gothenburg, Gothenburg, Sweden; Katia V Bloch: Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Anneke Blokstra: National Institute for Public Health and the Environment, Bilthoven, Netherlands; Simona Bo: University of Turin, Turin, Italy; Martin Bobak: University College London, London, United Kingdom; Lynne M Boddy: Liverpool John Moores University, Liverpool, United Kingdom; Bernhard O Boehm: Nanyang Technological University Singapore, Singapore, Singapore; Heiner Boeing: German Institute of Human Nutrition, Potsdam, Germany; Jose G Boggia: Universidad de la República, Montevideo, Uruguay; Elena Bogova: Endocrinology Research Centre, Moscow, Russian Federation; Carlos P Boissonnet: Centro de Educación Médica e Investigaciones Clínicas, Buenos Aires, Argentina; Stig E Bojesen: Copenhagen University Hospital, Copenhagen, Denmark; University of Copenhagen, Copenhagen, Denmark; Marialaura Bonaccio: IRCCS Neuromed, Pozzilli, Italy; Vanina Bongard: Toulouse University School of Medicine, Toulouse, France; Alice Funding Information: We thank WHO country and regional offices and World Heart Federation for support in data identification and access. The NCD-RisC database was funded by the Wellcome Trust. Maria LC Iurilli was supported by a Medical Research Council studentship. Sylvain Sebert received funding by the European Commission with grant agreements 633595 and 874739, respectively, for the DynaHEALTH and LongITools projects. The following contributors have deceased: Konrad Jamrozik, Altan Onat, Robespierre Ribeiro, Michael Sjöström, Agustinus Soemantri, Jutta Stieber, and Dimitrios Trichopou-los. The list of authors shows their last affiliation. Funding Information: Alison J Hayes: University of Sydney, Sydney, Australia; Nayu Ikeda: National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan; Rod T Jackson: University of Auckland, Auckland, New Zealand; Young-Ho Khang: Seoul National University, Seoul, Republic of Korea; Avula Laxmaiah: ICMR - National Institute of Nutrition, Hyderabad, India; Jing Liu: Capital Medical University Beijing An Zhen Hospital, Beijing, China; J Jaime Miranda: Universidad Peruana Cayetano Heredia, Lima, Peru; Olfa Saidi: University Tunis El Manar, Tunis, Tunisia; Sylvain Sebert: University of Oulu, Oulu, Finland; Maroje Sorić: University of Zagreb, Zagreb, Croatia; Gregor Starc: University of Ljubljana, Ljubljana, Slovenia; Edward W Gregg: Imperial College London, London, United Kingdom; Leandra Abarca-Gómez: Caja Costarricense de Seguro Social, San José, Costa Rica; Ziad A Abdeen: Al-Quds University, East Jerusalem, State of Palestine; Shynar Abdrakhmanova: National Center of Public Healthcare, Nur-Sultan, Kazakhstan; Suhaila Abdul Ghaffar: Ministry of Health, Kuala Lumpur, Malaysia; Hanan F Abdul Rahim: Qatar University, Doha, Qatar; Niveen M Abu-Rmeileh: Birzeit University, Birzeit, State of Palestine; Jamila Abubakar Garba: Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria; Benjamin Acosta-Cazares: Instituto Mexicano del Seguro Social, Mexico City, Mexico; Robert J Adams: Flinders University, Adelaide, Australia; Wichai Aekplakorn: Mahidol University, Nakhon Pathom, Thailand; Kaosar Afsana: BRAC James P Grant School of Public Health, Dhaka, Bangladesh; Shoaib Afzal: University of Copenhagen, Copenhagen, Denmark; Copenhagen University Hospital, Copenhagen, Denmark; Imelda A Agdeppa: Food and Nutrition Research Institute, Taguig, Philippines; Javad Aghazadeh-Attari: Urmia University of Medical Sciences, Urmia, Islamic Republic of Iran; Carlos A Aguilar-Salinas: Instituto Nacional de Ciencias Médicas y Nutrición, Mexico City, Mexico; Charles Agyemang: University of Amsterdam, Amsterdam, Netherlands; Mohamad Hasnan Ahmad: Ministry of Health, Kuala Lumpur, Malaysia; Noor Ani Ahmad: Ministry of Health, Kuala Lumpur, Malaysia; Ali Ahmadi: Shahrekord University of Medical Sciences, Shahrekord, Islamic Republic of Iran; Naser Ahmadi: Non-Communicable Diseases Research Center, Tehran, Islamic Republic of Iran; Soheir H Ahmed: University of Oslo, Oslo, Norway; Wolfgang Ahrens: University of Bremen, Bremen, Germany; Gulmira Aitmurzaeva: Republican Center for Health Promotion, Bishkek, Kyrgyzstan; Kamel Ajlouni: National Center for Diabetes, Endocrinology and Genetics, Amman, Jordan; Hazzaa M Al-Hazzaa: Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia; Badreya Al-Lahou: Kuwait Institute for Scientific Research, Kuwait City, Kuwait; Rajaa Al-Raddadi: King Abdulaziz University, Jeddah, Saudi Arabia; Monira Alarouj: Dasman Diabetes Institute, Kuwait City, Kuwait; Fadia AlBuhairan: Aldara Hospital and Medical Center, Riyadh, Saudi Arabia; Shahla AlDhukair: King Abdullah International Medical Research Center, Riyadh, Saudi Arabia; Mohamed M Ali: World Health Organization, Geneva, Switzerland; Abdullah Alkandari: Dasman Diabetes Institute, Kuwait City, Kuwait; Ala’a Alkerwi: Luxembourg Institute of Health, Strassen, Luxembourg; Kristine Allin: Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark; Mar Alvarez-Pedrerol: Barcelona Institute for Global Health CIBERESP, Barcelona, Spain; Eman Aly: World Health Organization Regional Office for the Eastern Mediterranean, Cairo, Egypt; Deepak N Amarapurkar: Bombay Hospital and Medical Research Centre, Mumbai, India; Parisa Amiri: Research Center for Social Determinants of Health, Tehran, Islamic Republic of Iran; Norbert Amougou: UMR CNRS-MNHN 7206 Eco-anthropologie, Paris, France; Philippe Amouyel: University of Lille, France; Lille University Hospital, Lille, France; Lars Bo Andersen: Western Norway University of Applied Sciences, Sogndal, Norway; Sigmund A Anderssen: Norwegian School of Sport Sciences, Oslo, Norway; Lars Ängquist: University of Copenhagen, Copenhagen, Denmark; Ranjit Mohan Anjana: Madras Diabetes Research Foundation, Chennai, India; Alireza Ansari-Moghaddam: Zahedan University of Medical Sciences, Zahedan, Islamic Republic of Iran; Hajer Aounallah-Skhiri: National Institute of Public Health, Tunis, Tunisia; Joana Araújo: Institute of Public Health of the University of Porto, Porto, Portugal; Inger Ariansen: Norwegian Institute of Public Health, Oslo, Norway; Tahir Aris: Ministry of Health, Kuala Lumpur, Malaysia; Raphael E Arku: University of Massachusetts Amherst, Amherst, United States; Nimmathota Arlappa: ICMR -National Institute of Nutrition, Hyderabad, India; Krishna K Aryal: Abt Associates, Kathmandu, Nepal; Thor Aspelund: University of Iceland, Reykjavik, Iceland; Felix K Assah: University of Yaoundé 1, Yaoundé, Cameroon; Maria Cecília F Assunc¸ão: Federal University of Pelotas, Pelotas, Brazil; May Soe Aung: University of Medicine 1, Yangon, Myanmar; Juha Auvinen: University of Oulu, Oulu, Finland; Oulu University Hospital, Oulu, Finland; Mária Avdicová: Publisher Copyright: © Copyright.
PY - 2021/3
Y1 - 2021/3
N2 - From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.
AB - From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions.
UR - http://www.scopus.com/inward/record.url?scp=85103837539&partnerID=8YFLogxK
U2 - 10.7554/eLife.60060
DO - 10.7554/eLife.60060
M3 - Article
C2 - 33685583
AN - SCOPUS:85103837539
SN - 2050-084X
VL - 10
JO - eLife
JF - eLife
M1 - e60060
ER -