Heterogeneity in Cancer: Cancer Stem Cells versus Clonal Evolution

Mark Shackleton, Elsa Quintana, Eric R. Fearon, Sean J. Morrison

Research output: Contribution to journalShort SurveyOtherpeer-review

830 Citations (Scopus)


The identification and characterization of cancer stem cells might lead to more effective treatments for some cancers by focusing therapy on the most malignant cells. To achieve this goal it will be necessary to determine which cancers follow a cancer stem cell model and which do not, to address technical issues related to tumorigenesis assays, and to test the extent to which cancer cell heterogeneity arises from genetic versus epigenetic differences.

Original languageEnglish
Pages (from-to)822-829
Number of pages8
Issue number5
Publication statusPublished - 4 Sep 2009
Externally publishedYes

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