Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

Christopher N Hahn, Chan Eng Chong, Catherine L. Carmichael, Ella J Wilkins, Peter J Brautigan, Xiao Chun Li, Milena Babic, Ming Lin, Amandine Carmagnac, Young Kyung Lee, Chung H Kok, Lucia Gagliardi, Kathryn L Friend, Paul G Ekert, Carolyn M. Butcher, Anna L Brown, Ian D. Lewis, Luen Bik To, Andrew E. Timms, Jan StorekSarah Moore, Meryl Altree, Robert Escher, Peter G. Bardy, Graeme K Suthers, Richard J D'Andrea, Marshall S. Horwitz, Hamish Steele Scott

Research output: Contribution to journalArticleResearchpeer-review

361 Citations (Scopus)

Abstract

We report the discovery of GATA2 as a new myelodysplastic syndrome (MDS)-acute myeloid leukemia (AML) predisposition gene. We found the same, previously unidentified heterozygous c.1061C>T (p.Thr354Met) missense mutation in the GATA2 transcription factor gene segregating with the multigenerational transmission of MDS-AML in three families and a GATA2 c.1063-1065delACA (p.Thr355del) mutation at an adjacent codon in a fourth MDS family. The resulting alterations reside within the second zinc finger of GATA2, which mediates DNA-binding and protein-protein interactions. We show differential effects of the mutations on the transactivation of target genes, cellular differentiation, apoptosis and global gene expression. Identification of such predisposing genes to familial forms of MDS and AML is critical for more effective diagnosis and prognosis, counseling, selection of related bone marrow transplant donors and development of therapies.

Original languageEnglish
Pages (from-to)1012-1019
Number of pages8
JournalNature Genetics
Volume43
Issue number10
DOIs
Publication statusPublished - Oct 2011
Externally publishedYes

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