Abstract
Impulsivity and compulsivity are traits relevant to a range of mental health problems and have traditionally been conceptualised as distinct constructs. Here, we reconceptualised impulsivity and compulsivity as partially overlapping phenotypes using a bifactor modelling approach and estimated heritability for their shared and unique phenotypic variance within a classical twin design. Adult twin pairs (N = 173) completed self-report questionnaires measuring psychological processes related to impulsivity and compulsivity. We fitted variance components models to three uncorrelated phenotypic dimensions: a general impulsive–compulsive dimension; and two narrower phenotypes related to impulsivity and obsessiveness.There was evidence of moderate heritability for impulsivity (A2 = 0.33), modest additive genetic or common environmental effects for obsessiveness (A2 = 0.25; C2 = 0.23), and moderate effects of common environment (C2 = 0.36) for the general dimension, This general impulsive–compulsive phenotype may reflect a quantitative liability to related mental health disorders that indexes exposure to potentially modifiable environmental risk factors.
| Original language | English |
|---|---|
| Article number | 14378 |
| Number of pages | 17 |
| Journal | Scientific Reports |
| Volume | 10 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1 Sept 2020 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- human behaviour
- psychology
Projects
- 2 Finished
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Enhancing and integrating addiction neuroscience knowledge with clinical practice, by transforming the approach to assessment and classification protocols, and improving outcomes by using neurocognitive phenotypes for tailored treatments
Yucel, M. (Primary Chief Investigator (PCI))
1/01/17 → 31/12/22
Project: Research
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Functional characterisation of genetic risk variants for ADHD: from Association to Biology
Hawi, Z. (Primary Chief Investigator (PCI)), Bellgrove, M. (Chief Investigator (CI)), Vance, A. L. A. (Chief Investigator (CI)) & Wallace, R. H. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/11 → 31/12/13
Project: Research
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