HER-2/neu expression in prostate adenocarcinoma: A systematic review and meta-analysis

Ary Serpa Neto, Marcos Tobias-Machado, Marcelo Langer Wroclawski, Fernando Luiz Affonso Fonseca, Gabriel Kushiyama Teixeira, Rodrigo Dal Moro Amarante, Eric Roger Wroclawski, Auro Del Giglio

Research output: Contribution to journalReview ArticleResearchpeer-review

38 Citations (Scopus)

Abstract

Purpose: HER-2/neu has been linked to the clinical progression of hormone independent prostate cancer. We performed a meta-analysis to investigate the prognostic impact of HER-2/neu over expression in patients with prostate adenocarcinoma, and its correlation with other pathological and clinical variables. Materials and Methods: We searched the MEDLINE®, Embase®, CancerLit® and ASCO® abstract databases for published studies of HER-2/neu protein expression in primary prostate cancer tissue with a median followup of greater than 2 years and data on survival in patients with and without HER-2/neu over expression. We separately analyzed studies reporting HER-2/neu soluble receptor levels in patients with prostate cancer. Results: We included 38 articles with a total of 5,976 patients. The overall RR of death in those with HER-2/neu over expression in the primary tumor was 1.63 (95% CI 1.471.82, p <0.0001). In the presence of over expression the recurrence RR was 1.87 (95% CI 1.592.21, p <0.0001). High HER-2/neu extracellular domain levels also correlated with death (RR 2.01, 95% CI 1.213.35, p = 0.007) and recurrence (RR 1.74, 95% CI 1.412.15, p <0.0001). Conclusions: There is a consistent association of HER-2/neu over expression and Gleason less than 7 with a higher RR of death and recurrence in patients with prostate cancer. Further clinical trials should test the hypothesis that HER-2/neu is a marker of a clinically worse outcome in patients with prostate cancer and a potential target for therapy.

Original languageEnglish
Pages (from-to)842-850
Number of pages9
JournalJournal of Urology
Volume184
Issue number3
DOIs
Publication statusPublished - Sep 2010
Externally publishedYes

Keywords

  • adenocarcinoma
  • genes, erbB-2
  • mortality
  • neoplasm recurrence, local
  • prostate

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